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Dual Chamber Delivery Systems190

Issue No #190 Sep/Oct 2026  September 23rd, 2026


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Issue 190 - Sep/Oct 2026

Inside the magazine

SIMPLIFYING COMBINATION THERAPIES: DUAL-INJECTION FUNCTIONALITY FOR EXISTING PLATFORM AUTOINJECTOR SYSTEMS
DUAL CHAMBER
Marc Flippe
BD (Becton Dickinson & Company)
SIMPLIFYING COMBINATION THERAPIES: DUAL-INJECTION FUNCTIONALITY FOR EXISTING PLATFORM AUTOINJECTOR SYSTEMS
Marc Flippe and Sophie Lelias discuss how dual-injection technology provides a promising approach to combination therapies and explain how, through the development of BD’s novel valve component, the company has reimagined dual injection within existing and established platform systems.
AHEAD OF THE CURVE: How Innovation Without Change<sup>®</sup> Delivers an End-to-End DUAL-CHAMBER Solution
DUAL CHAMBER
Sian Eden
Credence MedSystems
AHEAD OF THE CURVE: How Innovation Without Change® Delivers an End-to-End DUAL-CHAMBER Solution
Sian Eden and John Merhige consider how dual-chamber solutions have moved from a niche product to a mainstream consideration for stability-challenged formulations, offering formulation teams an alternative path to get these promising therapies into the hands of the patients that need them, and highlight how Credence is uniquely positioned to deliver on the potential of dual-chamber systems.
The Missing Middle of SC Drug Delivery: How a Dual-Cartridge Architecture Could Unlock the 3–10 mL Opportunity
DUAL CHAMBER
Dr Brent Buchine
Windgap Medical
The Missing Middle of SC Drug Delivery: How a Dual-Cartridge Architecture Could Unlock the 3–10 mL Opportunity
Dr Brent Buchine, Mike Ratigan and Aaron Mann argue that the industry’s traditional 2–3 mL boundary for subcutaneous injection reflects the limitations of conventional device and primary-container architectures more than the needs of any particular product or patient, considering whether two widely available cartridges, integrated into a single handheld system, could extend the simplicity and range of autoinjection.
Interview: Rethinking Drug Delivery for Increasingly Complex Therapies
INTERVIEW
Ram Halthore
KALEO
Interview: Rethinking Drug Delivery for Increasingly Complex Therapies
In this interview, Ram Halthore discusses the demands of newer classes of injectable drugs and the trend towards self-administration using conventional drug delivery systems, the requirements innovative systems must meet and the importance of selecting a delivery system early in formulation development, as well as the roles that robust human factors engineering and high reliability should play in device development.
LEVERAGING LARGE-VOLUME PLATFORMS FOR LIQUID-LIQUID DRUG DELIVERY
DUAL CHAMBER
Valerio Ravazzolo
Stevanato Group
LEVERAGING LARGE-VOLUME PLATFORMS FOR LIQUID-LIQUID DRUG DELIVERY
Valerio Ravazzolo and Thomas James examine liquid-liquid drug delivery using Stevanato Group’s EZ-fill® 3 mL internal-bypass cartridge platform and SHL Medical’s Magnitude 3.0 autoinjector platform, demonstrating how these technologies can be integrated into a standardised container-device ecosystem, helping to reduce the cost, risk and development timelines traditionally associated with customised solutions for combination products.
GAS-POWERED AUTOINJECTORS: MEETING THE CHALLENGES OF AN EVOLVING DRUG LANDSCAPE
DUAL CHAMBER
Ram Halthore
KALEO
GAS-POWERED AUTOINJECTORS: MEETING THE CHALLENGES OF AN EVOLVING DRUG LANDSCAPE
Ram Halthore presents Kaleo's Aerio™ autoinjector platform, discussing how gas-powered autoinjectors have the potential to tackle the challenges currently facing injectable drug delivery, including high-viscosity and large-volume formulations, increased demand for patient-centricity and stringent regulatory requirements for reliability in emergency-use applications.
CAPA VALVE LAUNCHES NEW VALVE SYSTEM FOR DUAL-CHAMBER DEVICES
DUAL CHAMBER
Dr Phil Green
Capa Valve
CAPA VALVE LAUNCHES NEW VALVE SYSTEM FOR DUAL-CHAMBER DEVICES
Dr Phil Green and Kevin Abbott discuss how Capa Valve’s patented valve technology provides a compelling alternative to bypass-based dual-chamber syringes, as its pressure-sensitive valve-based design enables much greater compatibility with existing fill-finish infrastructure and offers the flexibility to precisely tune the device via the geometric position of the valve within the syringe barrel.
PROACTIVE QUALITY AND REGULATORY ENGAGEMENT TO ACCELERATE PRODUCT DEVELOPMENT
PHARMA VIEW
Bharat Arora
PROACTIVE QUALITY AND REGULATORY ENGAGEMENT TO ACCELERATE PRODUCT DEVELOPMENT
Bharat Arora and Hirak Bhatiya Pharmaceuticals discuss the quality and regulatory perspective on accelerated development pathways transitioning from an emergency measure to a mainstream route to commercialisation, going over what may be expected of pharmaceutical quality teams to manage this new paradigm.
ENABLING DELIVERY OF LYOPHILISED BIOLOGICS VIA SIMULATION-LED DEVELOPMENT OF DUAL-CHAMBER SYSTEMS
EXPERT VIEW
Dr Sahab Babaee
ENABLING DELIVERY OF LYOPHILISED BIOLOGICS VIA SIMULATION-LED DEVELOPMENT OF DUAL-CHAMBER SYSTEMS
Dr Sahab Babaee and Dr Matthew Hancock discuss the potential of using modelling and simulation when designing dual-chamber injection devices, which can enable device designers to investigate the complex interactions that take place within a dual-chamber system without a physical prototype and discover potential failure modes much earlier in the design process.
UNSTACKING THE DUAL-CHAMBER SYRINGE: A CARTRIDGE-BASED PATH TO RELIABLE RECONSTITUTION
DUAL CHAMBER
Eric Sugalski
Ampulis
UNSTACKING THE DUAL-CHAMBER SYRINGE: A CARTRIDGE-BASED PATH TO RELIABLE RECONSTITUTION
Eric Sugalski and Tom Handel introduce Pristal, the cartridge-based reconstitution platform from Ampulis, and explain how it overcomes some of the usability, manufacturing and supply-chain challenges that have limited stacked dual-chamber syringes.
HIGH-CONCENTRATION, HIGH-VISCOSITY DELIVERY WITH CORE-ANNULAR FLOW
EARLY INSIGHT
Dr Simon Rufer
CoFlo Medical
HIGH-CONCENTRATION, HIGH-VISCOSITY DELIVERY WITH CORE-ANNULAR FLOW
Dr Simon Rufer and Pratik Mishra introduce CoFlo Medical ’s core-annular flow platform, which promises to eliminate the long-standing viscosity bottleneck for needle-based delivery. The company’s platform enables high-concentration, high-viscosity delivery for existing formulations without the need for reformulation or new compounds in a patient-friendly form.
RECONSTITUTION TO CO-DELIVERY: DESIGNING MULTICHAMBER DEVICES FOR BETTER PATIENT EXPERIENCES
EXPERT VIEW
Jack Dunkley
RECONSTITUTION TO CO-DELIVERY: DESIGNING MULTICHAMBER DEVICES FOR BETTER PATIENT EXPERIENCES
Jack Dunkley delves into the architectural principles of multichamber systems for injectable formulations and considers how to overcome the design challenges involved.
CONFERENCE PREVIEW: CPHI MILAN
CONFERENCE SHOWCASE
CONFERENCE PREVIEW: CPHI MILAN
The global pharmaceutical community is set to gather at Fiera Milano, Milan, Italy, October 6–8, 2026, for three days of insight, innovation and partnership across the pharmaceutical value chain.
Company Showcase: Grand River Aseptic Manufacturing
SHOWCASE
Chelsea Keeton
Grand River Aseptic Manufacturing
Company Showcase: Grand River Aseptic Manufacturing
Grand River Aseptic Manufacturing discusses its sterile filling capabilities and how its expanding facilities support growing demand for vial, syringe and cartridge filling.
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