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Injectable Drug Delivery: Formulations & Devices133

Issue No #133 May 2022 May 12th, 2022

Inside the magazine

PUTTING PROCESS ENGINEERING INTO ACTION

Jonathan Kearns

PUTTING PROCESS ENGINEERING INTO ACTION

Jonathan Kearns and Kevin Huang consider how engineering competencies are being driven to the next level by leveraging process engineering and how this can transform drug-device projects.

PREMIUMCOAT<sup>®</sup> SOLUTIONS: HELPING CONTROL THE LEVEL OF SILICONE TO PROTECT SENSITIVE THERAPEUTICS

PREFILLED SYRINGES

Sebastien Cordier

PREMIUMCOAT^® SOLUTIONS: HELPING CONTROL THE LEVEL OF SILICONE TO PROTECT SENSITIVE THERAPEUTICS

Sébastien Cordier, Vincent Holterboch and Estelle Verger discuss how coated elastomer components, such as Aptar Pharma’s PremiumCoat^®, can help drug developers optimise the balance between component processability and minimising silicone migration into a drug product.

IMPROVING CLINICAL OUTCOMES WITH A PATIENT-CENTRIC AND REUSABLE PEN PLATFORM

IMPROVING CLINICAL OUTCOMES WITH A PATIENT-CENTRIC AND REUSABLE PEN PLATFORM

Cécile Gross and Radosław Romańczuk discuss Nemera’s Pendura AD pen platform and present case studies demonstrating how it can be tailored to address the user’s needs and meet pharma industry constraints.

INJECTING THE FUTURE

INJECTING THE FUTURE

Simone Farina discusses Flex’s new smart autoinjector platform for the healthcare market, designed to enable original equipment manufacturers to accelerate time-to-market, reduce costs and boost reliability, while ensuring patient compliance.

CONNECTED DRUG DELIVERY – MAXIMISING ACCESS BY DESIGN

Jabil Healthcare

CONNECTED DRUG DELIVERY – MAXIMISING ACCESS BY DESIGN

Oliver Eden discusses the factors that drive the design and development of a reusable autoinjector solution. Foremost amongst these considerations is the patient, in terms of ease of use with the device itself and maximising access to the broadest possible population with a versatile, portfolio-enabling platform ready for the connected world.

ADVANCEMENTS AND EVOLUTION OF POWER SOURCES IN DRUG DELIVERY

ADVANCEMENTS AND EVOLUTION OF POWER SOURCES IN DRUG DELIVERY

William Welch considers the evolution of compressed gas alternatives to spring power for single-use drug delivery devices.

A CHECKLIST FOR AUTOINJECTOR DESIGN

A CHECKLIST FOR AUTOINJECTOR DESIGN

Michael Earl outlines the five key questions autoinjector designers typically ask during the development process and the choices available for tailoring autoinjector products.

EXCELLENCE THROUGH SIMPLICITY: PICCOJECT™ AUTOINJECTOR PLATFORM

Dr Fred Metzmann

EXCELLENCE THROUGH SIMPLICITY: PICCOJECT™ AUTOINJECTOR PLATFORM

Fred Metzmann and Chris Muenzer discuss the simplicity of the PiccoJect™ autoinjector platform and the company's commitment to sustainability.

Technology Showcase: CCBio’s Felice Dose

Technology Showcase: CCBio’s Felice Dose

CCBio introduces its wearable (on-body) injector, Felice Dose, which is capable of handling various drug volumes, concentrations and viscosities, as well as different injection speeds and delivery times.

OXYCAPT™: A SUPERIOR PRIMARY CONTAINER MATERIAL FOR BIOLOGICS AND GENE AND CELL THERAPIES

PREFILLED SYRINGES

Hiroki Hasegawa

Mitsubishi Gas Chemical

OXYCAPT™: A SUPERIOR PRIMARY CONTAINER MATERIAL FOR BIOLOGICS AND GENE AND CELL THERAPIES

Hiroki Hasegawa and Tomohiro Suzuki provide an overview of the OXYCAPT multilayer vial and syringe, along with a discussion of how OXYCAPT fares at low and very low temperatures.

EXTRACELLULAR VESICLE ENGINEERING: OPTIMISING NATURE’S NON-IMMUNOGENIC, DRUG DELIVERY PLATFORM

Dr Anna Cifuentes-Rius

EXTRACELLULAR VESICLE ENGINEERING: OPTIMISING NATURE’S NON-IMMUNOGENIC, DRUG DELIVERY PLATFORM

Anna Cifuentes-Rius discusses the exciting potential of extracellular vesicles to advance drug delivery, in particular their natural ability to carry API payloads across difficult-to-traverse biological barriers.

GLASS-FILLED CELANEX<sup>®</sup> MT<sup>®</sup> PBT HITS SWEET SPOT FOR BIOLOGICS AND REUSABLE DEVICES

GLASS-FILLED CELANEX^® MT^® PBT HITS SWEET SPOT FOR BIOLOGICS AND REUSABLE DEVICES

Bryan Deacon, Marnik Vaes and Peter Burke, introduce a medical-grade glass-filled engineering polymer, Celanex^® MT^® PBT 2406MT GF20, which fills a gap in the materials market between standard engineering thermoplastics and expensive high-performance polymers.

ENABLING A NEW PARADIGM FOR PEPTIDE DRUG DEVELOPMENT

Xeris Pharmaceuticals

ENABLING A NEW PARADIGM FOR PEPTIDE DRUG DEVELOPMENT

Michael Neely reviews peptide formulations and introduces Xeris's XeriSol™ technology and its potential paradigm-changing capabilities.

RECENT TRENDS & DEVELOPMENTS IN INJECTABLE FORMULATION & DELIVERY

Dr Martin Gonzalez

RECENT TRENDS & DEVELOPMENTS IN INJECTABLE FORMULATION & DELIVERY

Martin Gonzalez details current trends in sterile injectable formulations and their delivery devices, and the challenges pharma and its contract development and manufacturing company partners face in bringing emerging breakthroughs to market.

INTERVIEW: STEVEN KAUFMAN, STEVANATO GROUP, & MICHAEL EARL, OWEN MUMFORD

Stevanato Group

INTERVIEW: STEVEN KAUFMAN, STEVANATO GROUP, & MICHAEL EARL, OWEN MUMFORD

In this exclusive interview, Steven Kaufman of Stevanato Group, and Michael Earl of Owen Mumford, talked with us about their companies' recent major agreement for the manufacturing and provision of prefillable syringes for the advanced two-step, single-use autoinjector, Aidaptus^®.

INTERVIEW: AURELIO ARIAS, IQVIA

INTERVIEW: AURELIO ARIAS, IQVIA

Aurelio Arias of IQVIA discusses trends in the drug delivery industry, including how device and packaging manufacturers are increasingly aligning as strategic partners to speed innovation and reduce reliance on pharma investment.

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