Pulmonary & Nasal Delivery92

Issue No #92 November 19th, 2018

Issue 92 - Nov 2018

Inside the magazine

NEBULISERS: TIME TO REINVENT THE WHEEL

Dr John N Pritchard

NEBULISERS: TIME TO REINVENT THE WHEEL

John Pritchard discusses the history of the nebuliser, its fall in popularity with the advent of DPIs and pMDIs, and its current resurgence due to the success of the mesh nebuliser, continuing on to how changing the development paradigm to utilise nebuliser technology more effectively can have significant benefits.

INHALABLE THERAPEUTIC BIOLOGICS, A PARADIGM SHIFT FOR NON-INVASIVE EFFICIENT MEDICAL TREATMENTS

Susana Ecenarro Probst

INHALABLE THERAPEUTIC BIOLOGICS, A PARADIGM SHIFT FOR NON-INVASIVE EFFICIENT MEDICAL TREATMENTS

Susana Ecenarro Probst and Francesca Buttini discuss the rising prominence of biologics in the pharmaceuticals market and how dry powder inhalers utilising hard capsules are a promising potential delivery method for these new drugs.

CITRUS FRUITS INSPIRE THE NEXT GENERATION OF AIRBORNE DRUG DELIVERY

Dr Andrew K Dickerson

Fluids and Structures (FaST) Laboratory

CITRUS FRUITS INSPIRE THE NEXT GENERATION OF AIRBORNE DRUG DELIVERY

Andrew Dickerson discusses recent research undertaken by his team into the mechanics of liquid microjets created naturally by citrus fruits, and how they could be the key to a new design of drug delivery device.

BILL WELCH, PHILLIPS-MEDISIZE & JOHN PATTON, DANCE BIOPHARM

Aerami Therapeutics

BILL WELCH, PHILLIPS-MEDISIZE & JOHN PATTON, DANCE BIOPHARM

In this exclusive interview with ONdrugDelivery Magazine, Bill Welch and John Patton discuss inhaled insulin, connectivity and their two companies’ close partnership

REDUCING VARIABILITY IN TEST RESULTS FOR OINDPS WITH AUTOMATED ACTUATION

Proveris Scientific

REDUCING VARIABILITY IN TEST RESULTS FOR OINDPS WITH AUTOMATED ACTUATION

Heli Chauhan and Linda (Lingzhi) Liao discuss the importance of automated actuation for testing inhalation and spray devices to avoid variability introduced by manual method.

NASAL DRUG DELIVERY VIA THE ORAL ROUTE USING A PMDI

Dr Laurent Vecellio

NASAL DRUG DELIVERY VIA THE ORAL ROUTE USING A PMDI

Laurent Vecellio, Déborah Le Pennec and Alain Regard, Technology Product Manage discuss a study Nemera has funded into the retronose concept, using a pMDI to deliver to the nasal cavity via the oral route during exhalation through the nose.

PIPELINE TRENDS AND CHALLENGES IN PULMONARY DELIVERY

Dr Gunilla Petersson

PIPELINE TRENDS AND CHALLENGES IN PULMONARY DELIVERY

Gunilla Petersson provides an overview of the inhalables sector from a pharma perspective, covering the three major device types – DPIs, pMDIs and nebulisers.

VARIABILITY IN CASCADE IMPACTION: SOURCES, IMPACT AND STRATEGIES FOR REDUCTION

Copley Scientific

VARIABILITY IN CASCADE IMPACTION: SOURCES, IMPACT AND STRATEGIES FOR REDUCTION

Mark Copley considers cascade impaction as a method for determining the aerodynamic particle size distribution of orally inhaled drug products, and how techniques to improve air flow control and semi-automation of the process can significantly reduce the variability involved.

MANUFACTURING DPIS: AN ENGINEERING PERSPECTIVE

MANUFACTURING DPIS: AN ENGINEERING PERSPECTIVE

Pietro Pirera and Stefano Crivellaro discuss the rising prominence of the DPI in inhalable drug delivery, how this has been facilitated by industrial filling technologies and how dosators in particular provide high-precision industrial-scale filling.

INTERTEK’S CENTRE OF EXCELLENCE FOR INHALED AND NASAL BIOLOGICS

Intertek Pharmaceutical Services

INTERTEK’S CENTRE OF EXCELLENCE FOR INHALED AND NASAL BIOLOGICS

Chris Vernall discusses the significance and difficulties of biologics in the inhalables sector, and how Intertek’s Centre of Excellence for Inhaled and Nasal Biologics provides valuable services for those developing products in this area.

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