Pulmonary & Nasal Delivery
Issue No #114 Nov 2020
November 27th, 2020
Inside the magazine
AN ADVANCED CUSTOMISABLE COMPREHENSIVE DPI CAPSULE PORTFOLIO OFFERING
Frédérique Bordes-Picard and Julien Lamps discuss the factors driving development in the area of capsule-based dry powder inhalers, and how the company’s Capsugel
Zephyr™ portfolio offering is perfectly positioned to meet and exceed industry’s growing and evolving requirements.
DEVELOPMENT & PRODUCTION OF RESPIMAT
REUSABLE INHALER HOUSING MODULE
Josef Schmid, Markus Müller and Nina Zielonka discuss Gerresheimer’s recent work on developing the housing module for Boehringer Ingelheim’s new version of the Respimat
Edgar Hernan Cuevas Brun
AN INTRODUCTION TO SMART BREATH-ACTUATED NEBULISERS
Edgar Hernan Cuevas Brun considers the benefits of smart breath-actuated nebulisers and looks at the latest technology contributing to the evolution of nebulisers.
ONE-STOP SHOP FOR TOTAL MIXING SOLUTIONS FOR PHARMACEUTICAL MANUFACTURERS
Bert Dekens discusses Hosokawa Micron's offering for pharmaceutical powder mixing, including the Cyclomix high-shear mixer and the Nauta low-shear mixer, and how the company’s technology solutions take a broader approach to the full mixing process than simply providing a mixing machine.
INTRANASAL DELIVERY OF BIOLOGIC THERAPEUTICS AND VACCINES
David Ward looks at how the nasal route of drug administration offers the potential to improve the delivery of biologics, even for very complex molecules such as antibodies – and why strategic formulation is required to make this a reality.
SEMI-AUTOMATION IN INHALER TESTING – EXPLORING THE POTENTIAL AND PRACTICALITIES
João Pereira, Raquel Borda D’Água, Mark Copley and Anna Sipitanou, discuss the semi-automation of cascade impactor testing and the benefits it can bring in terms of quality of orally inhaled product test data, and reductions in cost and effort associated with routine, critical measurements.
Kindeva Drug Delivery
COLD FILLING VERSUS PRESSURE FILLING: THE CASE FOR VERSATILE, FULLY INTEGRATED CDMOs
Steve Haswell compares the two main processes for manufacturing pressurised metered dose inhalers – and examines the value for pharmaceutical companies of working with contract development and manufacturing organisations that have expertise in both processes.
ECONOMIC OPERATORS UNDER THE EU MDR: THE NEW REQUIREMENTS
Beth Crandall spells out the new requirements for Economic Operators under the EU Medical Device Regulation.
Dr Richard Johnson
Upperton Pharma Solutions
™: ENGINEERING SPRAY-DRIED POWDERS FOR PULMONARY DELIVERY
Richard Johnson discusses the techniques of jet milling and spray drying for the production of formulations for dry powder inhalers, and introduces Upperton Pharma’s Pulmo
™ technology, which combines the advantages of both.
Dr Sion Coulman
EVALUATING THE MECHANICAL PROPERTIES OF “EXTRA DRY” HARD-SHELL CAPSULES
Sion Coulman, Siamac Parker, Prof James Birchall, Susana Ecenarro and Mahmoud Farag discuss new developments in low moisture content capsule technology for hygroscopic and very moisture-labile APIs.
THE UNTOLD STORY OF NEMERA’S INHALATION FRANCHISE
Raphaële Audibert and Niyati Sapatnekar tell the story of Nemera’s journey from contract manufacturer to end-to-end inhalation partner.
HOW EMOTIONAL INTELLIGENCE IS DRIVING IMPROVEMENTS & MEETING CHALLENGES IN PULMONARY DELIVERY
Howard Burnett explores how emotional intelligence can foster partnerships that have the potential to drive advances in understanding and improving patient outcomes, and presents the case for a single-source, turnkey approach to pulmonary solution development.
MG2 AUTOMATION SOLUTIONS FOR INHALATION: R&D, TECHNOLOGICAL PARTNERSHIPS & SUCCESSFUL CASE HISTORIES
Italian automation solutions provider MG2 describes its offering in the inhalation space, including unique benefits of collaboration and two example partnerships.
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