Pulmonary & Nasal Delivery114

Issue No #114 Nov 2020 November 27th, 2020

Inside the magazine

AN ADVANCED CUSTOMISABLE COMPREHENSIVE DPI CAPSULE PORTFOLIO OFFERING

Frédérique Bordes-Picard

AN ADVANCED CUSTOMISABLE COMPREHENSIVE DPI CAPSULE PORTFOLIO OFFERING

Frédérique Bordes-Picard and Julien Lamps discuss the factors driving development in the area of capsule-based dry powder inhalers, and how the company’s Capsugel^® Zephyr™ portfolio offering is perfectly positioned to meet and exceed industry’s growing and evolving requirements.

DEVELOPMENT & PRODUCTION OF RESPIMAT<sup>®</sup> REUSABLE INHALER HOUSING MODULE

DEVELOPMENT & PRODUCTION OF RESPIMAT^® REUSABLE INHALER HOUSING MODULE

Josef Schmid, Markus Müller and Nina Zielonka discuss Gerresheimer’s recent work on developing the housing module for Boehringer Ingelheim’s new version of the Respimat inhaler.

AN INTRODUCTION TO SMART BREATH-ACTUATED NEBULISERS

Edgar Hernan Cuevas Brun

HCmed Innovations

AN INTRODUCTION TO SMART BREATH-ACTUATED NEBULISERS

Edgar Hernan Cuevas Brun considers the benefits of smart breath-actuated nebulisers and looks at the latest technology contributing to the evolution of nebulisers.

ONE-STOP SHOP FOR TOTAL MIXING SOLUTIONS FOR PHARMACEUTICAL MANUFACTURERS

INDUSTRIALISATION

Hosokawa Micron

ONE-STOP SHOP FOR TOTAL MIXING SOLUTIONS FOR PHARMACEUTICAL MANUFACTURERS

Bert Dekens discusses Hosokawa Micron's offering for pharmaceutical powder mixing, including the Cyclomix high-shear mixer and the Nauta low-shear mixer, and how the company’s technology solutions take a broader approach to the full mixing process than simply providing a mixing machine.

INTRANASAL DELIVERY OF BIOLOGIC THERAPEUTICS AND VACCINES

Intertek Melbourn

INTRANASAL DELIVERY OF BIOLOGIC THERAPEUTICS AND VACCINES

David Ward looks at how the nasal route of drug administration offers the potential to improve the delivery of biologics, even for very complex molecules such as antibodies – and why strategic formulation is required to make this a reality.

SEMI-AUTOMATION IN INHALER TESTING – EXPLORING THE POTENTIAL AND PRACTICALITIES

SEMI-AUTOMATION IN INHALER TESTING – EXPLORING THE POTENTIAL AND PRACTICALITIES

João Pereira, Raquel Borda D’Água, Mark Copley and Anna Sipitanou, discuss the semi-automation of cascade impactor testing and the benefits it can bring in terms of quality of orally inhaled product test data, and reductions in cost and effort associated with routine, critical measurements.

COLD FILLING VERSUS PRESSURE FILLING: THE CASE FOR VERSATILE, FULLY INTEGRATED CDMOs

Kindeva Drug Delivery

COLD FILLING VERSUS PRESSURE FILLING: THE CASE FOR VERSATILE, FULLY INTEGRATED CDMOs

Steve Haswell compares the two main processes for manufacturing pressurised metered dose inhalers – and examines the value for pharmaceutical companies of working with contract development and manufacturing organisations that have expertise in both processes.

ECONOMIC OPERATORS UNDER THE EU MDR: THE NEW REQUIREMENTS

ECONOMIC OPERATORS UNDER THE EU MDR: THE NEW REQUIREMENTS

Beth Crandall spells out the new requirements for Economic Operators under the EU Medical Device Regulation.

PULMO<emp>CRAFT</emp>™: ENGINEERING SPRAY-DRIED POWDERS FOR PULMONARY DELIVERY

Dr Richard Johnson

Upperton Pharma Solutions

PULMOCRAFT™: ENGINEERING SPRAY-DRIED POWDERS FOR PULMONARY DELIVERY

Richard Johnson discusses the techniques of jet milling and spray drying for the production of formulations for dry powder inhalers, and introduces Upperton Pharma’s PulmoCraft™ technology, which combines the advantages of both.

EVALUATING THE MECHANICAL PROPERTIES OF “EXTRA DRY” HARD-SHELL CAPSULES

Dr Sion Coulman

Cardiff University

EVALUATING THE MECHANICAL PROPERTIES OF “EXTRA DRY” HARD-SHELL CAPSULES

Sion Coulman, Siamac Parker, Prof James Birchall, Susana Ecenarro and Mahmoud Farag discuss new developments in low moisture content capsule technology for hygroscopic and very moisture-labile APIs.

THE UNTOLD STORY OF NEMERA’S INHALATION FRANCHISE

Raphaële Audibert

THE UNTOLD STORY OF NEMERA’S INHALATION FRANCHISE

Raphaële Audibert and Niyati Sapatnekar tell the story of Nemera’s journey from contract manufacturer to end-to-end inhalation partner.

HOW EMOTIONAL INTELLIGENCE IS DRIVING IMPROVEMENTS & MEETING CHALLENGES IN PULMONARY DELIVERY

HOW EMOTIONAL INTELLIGENCE IS DRIVING IMPROVEMENTS & MEETING CHALLENGES IN PULMONARY DELIVERY

Howard Burnett explores how emotional intelligence can foster partnerships that have the potential to drive advances in understanding and improving patient outcomes, and presents the case for a single-source, turnkey approach to pulmonary solution development.

MG2 AUTOMATION SOLUTIONS FOR INHALATION: R&D, TECHNOLOGICAL PARTNERSHIPS & SUCCESSFUL CASE HISTORIES

MG2 AUTOMATION SOLUTIONS FOR INHALATION: R&D, TECHNOLOGICAL PARTNERSHIPS & SUCCESSFUL CASE HISTORIES

Italian automation solutions provider MG2 describes its offering in the inhalation space, including unique benefits of collaboration and two example partnerships.