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INJECTION
DUAL CHAMBER
FORMULATION
PFS
WEARABLES
ALL INJECTION
OCULAR
ORAL
RESPIRATORY
PULMONARY
NASAL
ALL RESPIRATORY
MORE
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EXPERT VIEWS
EARLY INSIGHTS
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THE MAGAZINE
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Pulmonary & Nasal Drug Delivery
127
Issue No #127 Nov 2021
November 17th, 2021
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Issue 127 - Nov 2021
Inside the magazine
PULMONARY
Deborah Norris
Cambridge Design Partnership
WAITING FOR THE OUTBREATH – WHAT CAN COVID-19 BIOAEROSOL RESEARCH TELL US ABOUT INHALABLE DRUG DELIVERY?
Deborah Norris, Mark Allen, Karl Hewson and Karla Sanchez, discuss how the covid-19 pandemic has spurred research in the pulmonary space, which suggests that a patient-tailored approach based on their individual lung characteristics, facilitated by advanced technology, could improve patient health outcomes and quality of life.
PULMONARY
Siamac Parker
Qualicaps
CHARACTERISING WALL THICKNESS OF QUALI-V
®
-I CAPSULES & ITS EFFECT ON CAPSULE PUNCTURE BY A DPI PIN
Siamac Parker, Sion Coulman, Prof James Birchall alongside Susana Ecenarro and Mahmoud Farag, present a study that uses optical coherence tomography to characterise the wall thickness of capsules at the dome position and investigates the importance of controlling the dome thickness of hard-shell capsules to be used in a dry powder inhaler.
EXPERT VIEW
Robert Lee
ADDRESSING THE CHALLENGES OF NASAL BIOTHERAPEUTIC DRUG DELIVERY
Robert Lee discusses the benefits of administering drugs to the nasal cavity, as well as the main challenges in formulation for this route and the strategies that can be applied to overcome them.
CONNECTIVITY
Andreas Meliniotis
Phillips Medisize
MAKING THE CONNECTION BETWEEN EFFICACY AND ENVIRONMENTAL SUSTAINABILITY
Andreas Meliniotis looks at the factors that should be considered when designing devices with a view to sustainable connectivity.
EXPERT VIEW
Dr Joana Pinto
POWDER CHARACTERISATION: A CRITICAL TOOL FOR THE EVOLUTION OF INHALED DRUG DELIVERY
Jamie Clayton, Joana Pinto and Sarah Zellnitz discuss the benefits of multi-faceted powder characterisation in dry powder inhalation formulations and how it can support efforts to achieve net zero emissions.
PULMONARY
Raphaële Audibert
Nemera
LEVERAGING HUMAN FACTORS TO DEVELOP PATIENT-CENTRIC INHALERS
Raphaële Audibert, Mark Tunkel and Manuela Basso look at the role patient-centricity has to play in the development of inhalers to treat chronic respiratory diseases.
PHARMA VIEW
Dr Andrea Benassi
NUMERICAL SIMULATIONS FOR INHALATION PRODUCT DEVELOPMENT: ACHIEVEMENTS AND CURRENT LIMITATIONS
Andrea Benassi and Ciro Cottini discuss the current state of CFD and DEM computational modelling, how it is used to improve inhaler design and manufacturing, and what the current limitations of this technology are, as well as how those limitations may be overcome.
NASAL
Mark Copley
Copley Scientific
IMPROVING IN VITRO TEST METHODS FOR NASAL DRUG PRODUCTS
Mark Copley and Anna Sipitanou look at how in vitro testing is being refined for greater repeatability to maximise its value as a low-cost tool for product development, including an assessment of the role of automation in improving the sensitivity of in vitro testing.
SUSTAINABILITY
Howard Burnett
Aptar Pharma
TOWARDS A MORE SUSTAINABLE FUTURE WITH pMDI SOLUTIONS
Howard Burnett, Chris Baron and Jay Bhogaita summarise the findings of a recent forum that looked at the development of more sustainable pressurised metered dose inhalers.
NASAL
Dr Julie Suman
Aptar Pharma
DELIVERING ON THE PROMISES OF INTRANASAL VACCINATION
Julie Suman and Nektaria Karavas review intranasal delivery as a method of vaccine administration and consider the challenges and benefits of intranasal delivery.
PULMONARY
Edgar Hernan Cuevas Brun
HCmed Innovations
DELIVERING SUSPENSIONS WITH MESH TECHNOLOGY
Edgar Hernan Cuevas Brun and Yuan-Ming Hsu discuss the performance of mesh nebulisers for the delivery of suspensions in inhalation therapy.
ROUNDTABLE
Frédérique Bordes-Picard
Lonza
ROUNDTABLE: CAPSULE-BASED DRY POWDER INHALERS
Frédérique Bordes-Picard of Lonza, Marco Franza of Berry, Mirjam Kobler of Meggle, and Marco Laackmann of Harro Höfliger, discuss the accelerating development potential of capsule-based dry powder inhalers (DPIs) and the potential of these effective and efficient drug delivery devices in the modern drug delivery market.
PULMONARY
Bas van Driel
DFE Pharma
TRANSFORMING DRUG DELIVERY WITH SYNERGISTIC WORKING
Bas van Driel discusses how expert collaborations can help develop a knowledge base to transform drug delivery and manufacturing. He shares how recent collaborative research projects involving lactose-based dry powder inhalation formulations, with and without magnesium stearate and lactose as an excipient in 3D tablet printing, have done just that.
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