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INJECTION
DUAL CHAMBER
FORMULATION
PFS
WEARABLES
ALL INJECTION
OCULAR
ORAL
RESPIRATORY
PULMONARY
NASAL
ALL RESPIRATORY
SKIN
SUSTAINABILITY
MORE
INTERVIEWS
EXPERT VIEWS
EARLY INSIGHTS
COMPANY LISTINGS
OUR AUTHORS
THE MAGAZINE
EVENTS
ED CALENDAR
MEDIA PACK
CONTRIBUTE
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DUAL CHAMBER
DUAL CHAMBER
CAPA VALVE LAUNCHES NEW VALVE SYSTEM FOR DUAL-CHAMBER DEVICES
Dr Phil Green and Kevin Abbott discuss how Capa Valve’s patented valve technology provides a compelling alternative to bypass-based dual-chamber syringes, as its pressure-sensitive valve-based design enables much greater compatibility with existing fill-finish infrastructure and offers the flexibility to precisely tune the device via the geometric position of the valve within the syringe barrel.
DUAL CHAMBER
UNSTACKING THE DUAL-CHAMBER SYRINGE: A CARTRIDGE-BASED PATH TO RELIABLE RECONSTITUTION
Eric Sugalski and Tom Handel introduce Pristal, the cartridge-based reconstitution platform from Ampulis, and explain how it overcomes some of the usability, manufacturing and supply-chain challenges that have limited stacked dual-chamber syringes.
PREFILLED SYRINGES
Dr Jakob Lange
Ypsomed
FOR THE RECORD: HOW PAST EXPERIENCE ENABLES FUTURE SUCCESS
Dr Jakob Lange and Shawn James discuss the value of the experience hidden behind metrics such as completed projects and commercialised devices – the wealth of accumulated process knowledge that enables a company to bring hard-learned lessons forwards to benefit each new development programme and evolve its product portfolio to meet the needs of an evolving sector.
INJECTION
Iker Ibisate
RPK Medical
ENGINEERING THE NEXT GENERATION OF AUTOINJECTORS
Iker Ibisate examines the significant potential of springs and stamped metal components to broaden the design space for autoinjector platform developers by condensing an increasing array of key functions into a minimal number of high-precision parts.
SHOWCASE
Chelsea Keeton
Grand River Aseptic Manufacturing
Company Showcase: Grand River Aseptic Manufacturing
Grand River Aseptic Manufacturing discusses its sterile filling capabilities and how its expanding facilities support growing demand for vial, syringe and cartridge filling.
DUAL CHAMBER
Marc Flippe
BD (Becton Dickinson & Company)
SIMPLIFYING COMBINATION THERAPIES: DUAL-INJECTION FUNCTIONALITY FOR EXISTING PLATFORM AUTOINJECTOR SYSTEMS
Marc Flippe and Sophie Lelias discuss how dual-injection technology provides a promising approach to combination therapies and explain how, through the development of BD’s novel valve component, the company has reimagined dual injection within existing and established platform systems.
DUAL CHAMBER
Sian Eden
Credence MedSystems
AHEAD OF THE CURVE: How Innovation Without Change
®
Delivers an End-to-End DUAL-CHAMBER Solution
Sian Eden and John Merhige consider how dual-chamber solutions have moved from a niche product to a mainstream consideration for stability-challenged formulations, offering formulation teams an alternative path to get these promising therapies into the hands of the patients that need them, and highlight how Credence is uniquely positioned to deliver on the potential of dual-chamber systems.
DUAL CHAMBER
Dr Brent Buchine
Windgap Medical
The Missing Middle of SC Drug Delivery: How a Dual-Cartridge Architecture Could Unlock the 3–10 mL Opportunity
Dr Brent Buchine, Mike Ratigan and Aaron Mann argue that the industry’s traditional 2–3 mL boundary for subcutaneous injection reflects the limitations of conventional device and primary-container architectures more than the needs of any particular product or patient, considering whether two widely available cartridges, integrated into a single handheld system, could extend the simplicity and range of autoinjection.
INTERVIEW
Ram Halthore
KALEO
Interview: Rethinking Drug Delivery for Increasingly Complex Therapies
In this interview, Ram Halthore discusses the demands of newer classes of injectable drugs and the trend towards self-administration using conventional drug delivery systems, the requirements innovative systems must meet and the importance of selecting a delivery system early in formulation development, as well as the roles that robust human factors engineering and high reliability should play in device development.
DUAL CHAMBER
Valerio Ravazzolo
Stevanato Group
LEVERAGING LARGE-VOLUME PLATFORMS FOR LIQUID-LIQUID DRUG DELIVERY
Valerio Ravazzolo and Thomas James examine liquid-liquid drug delivery using Stevanato Group’s EZ-fill
®
3 mL internal-bypass cartridge platform and SHL Medical’s Magnitude 3.0 autoinjector platform, demonstrating how these technologies can be integrated into a standardised container-device ecosystem, helping to reduce the cost, risk and development timelines traditionally associated with customised solutions for combination products.
DUAL CHAMBER
Ram Halthore
KALEO
GAS-POWERED AUTOINJECTORS: MEETING THE CHALLENGES OF AN EVOLVING DRUG LANDSCAPE
Ram Halthore presents Kaleo's Aerio™ autoinjector platform, discussing how gas-powered autoinjectors have the potential to tackle the challenges currently facing injectable drug delivery, including high-viscosity and large-volume formulations, increased demand for patient-centricity and stringent regulatory requirements for reliability in emergency-use applications.
PHARMA VIEW
Bharat Arora
PROACTIVE QUALITY AND REGULATORY ENGAGEMENT TO ACCELERATE PRODUCT DEVELOPMENT
Bharat Arora and Hirak Bhatiya Pharmaceuticals discuss the quality and regulatory perspective on accelerated development pathways transitioning from an emergency measure to a mainstream route to commercialisation, going over what may be expected of pharmaceutical quality teams to manage this new paradigm.
EXPERT VIEW
Dr Sahab Babaee
ENABLING DELIVERY OF LYOPHILISED BIOLOGICS VIA SIMULATION-LED DEVELOPMENT OF DUAL-CHAMBER SYSTEMS
Dr Sahab Babaee and Dr Matthew Hancock discuss the potential of using modelling and simulation when designing dual-chamber injection devices, which can enable device designers to investigate the complex interactions that take place within a dual-chamber system without a physical prototype and discover potential failure modes much earlier in the design process.
EARLY INSIGHT
Dr Simon Rufer
CoFlo Medical
HIGH-CONCENTRATION, HIGH-VISCOSITY DELIVERY WITH CORE-ANNULAR FLOW
Dr Simon Rufer and Pratik Mishra introduce CoFlo Medical ’s core-annular flow platform, which promises to eliminate the long-standing viscosity bottleneck for needle-based delivery. The company’s platform enables high-concentration, high-viscosity delivery for existing formulations without the need for reformulation or new compounds in a patient-friendly form.
EXPERT VIEW
Jack Dunkley
RECONSTITUTION TO CO-DELIVERY: DESIGNING MULTICHAMBER DEVICES FOR BETTER PATIENT EXPERIENCES
Jack Dunkley delves into the architectural principles of multichamber systems for injectable formulations and considers how to overcome the design challenges involved.
INDUSTRIALISATION
Christy Chen
SHL Advantec
INNOVATION AND AUTOMATION REUNITED – ENABLING SCALABLE FINAL ASSEMBLY FOR CARTRIDGE-BASED AUTOINJECTORS
Using SHL Medical's Reunite™ dual-chamber autoinjector and SHL Advantec's AOU™ assembly machine platform as a case study, Christy Chen and Alberto Flores explore the critical synergy between flexible automation architecture and expert final assembly services.
INJECTION
Landon Goldfarb
Instron
Testing Prefilled Syringes to ISO 11040
Instron's Landon Goldfarb talks through ISO 11040, a testing standard that addresses the design and functional properties of prefilled syringes.
INJECTION
Girum Yemane-Tekeste
Kindeva
AUTOINJECTOR TECHNOLOGY FOR AUTOMATIC MICROPARTICLE SUSPENSION AND INJECTION
Girum Yemane-Tekeste and Stephen Leslie share how Kindeva is building on its experience and history of innovation to develop an enabling technology for injectable microparticles and then evaluating it through proof-of-principle testing.
VIDEO
John Merhige
Credence MedSystems
Dual-Chamber Syringes, New Partnerships, and Speed-to-Market Pressures Shape 2026
John Merhige outlines his key themes shaping drug delivery in 2026: new momentum from a dual-chamber syringe fill-finish collaboration, a newly announced commercial supply agreement with a major global pharma company, and growing pressure to deliver increasingly complex molecules faster and more efficiently.
EXPERT VIEW
Tom Oakley
TRENDS FOR 2026
A new reality is forming as we enter 2026 – it will not be “business as usual”. Geopolitical forces in the largest market for pharmaceuticals, the US, are likely to mean substantial changes. Here, Tom Oakley and Alex Vasiev cover those changes, the incretin juggernaut and the march of technical progress with “minitablet” dispensers, large-volume injectors and dual-chamber devices.
EXPERT VIEW
Tim Quigg
THE PLATFORM PARADOX: DEVICE DEVELOPMENT CHALLENGES WITHIN FAST EVOLVING DRUG DISCOVERY PIPELINES
Tim Quigg, Mariam Al-Amari and Joel Gresham discuss how to enable high-dose delivery for novel biologics, using
ex vivo
and
in silico
approaches to accelerate drug-device development and improve device performance, thus de-risking projects and saving costs.
PHARMA VIEW
Conor O'Neill
GSK
ADOPTION OF SUSTAINABILITY PRACTICES WITHIN SUBCUTANEOUS DRUG DELIVERY: INDUSTRY INSIGHTS
Conor O’Neill (GSK), Duncan Paterson (AstraZeneca) and Dr Monica Adams (GSK) come together to discuss a recent study conducted by the Subcutaneous Drug Development & Delivery Consortium among its member organisations, digging into the pharmaceutical industry’s progress and priorities when it comes to improving the environmental impact of subcutaneous medicines.
INTERVIEW
Laxman Halleppanavar
Credence MedSystems
Interview: Making Dual-Chamber Systems a Viable Alternative
In this exclusive interview, Laxman Halleppanavar and Guy Furness discuss industry trends and challenges with injectable delivery, and how Credence MedSystems' dual-chamber devices provide solutions to address those challenges. Mr Halleppanavar goes into details of Credence’s role in this increasingly important sector of the drug delivery market, explaining the company’s approach to device design, development and overcoming the barriers posed by supply chain management.
INDUSTRIALISATION
Matthias Müller
Contexo
HIGH SPEED LASER ASSEMBLY – FLEXIBLE MACHINE CONCEPTS WITH FULL LASER INTEGRATION
Matthias Müller discusses the advantages of including laser technology in drug delivery device manufacturing, covering the various ways in which this technology can be applied and used to provide efficient, cost-effective and clean processes at high throughput rates.
DUAL CHAMBER
Marc Flippe
BD (Becton Dickinson & Company)
DE-RISKING A NOVEL VALVE COMPONENT FOR USE WITH STANDARD SYRINGE AND AUTOINJECTOR PLATFORMS
Marc Flippe and Sophie Lelias introduce a novel valve component designed to enable dual-chamber functionality within standard syringe and autoinjector platforms. Developed through a comprehensive modelling and development framework, the BD dual-injection syringe system provides a scalable solution to dual-chamber injection that reduces the burden of change by preserving compatibility with established container formats and device architectures.
DUAL CHAMBER
Bjørn Knud Andersen
Phillips Medisize
IMPROVING THE SELF-ADMINISTRATION OF LYO- AND LIQUID-LIQUID FORMULATIONS
Bjørn Andersen and Iain Simpson explore the factors contributing to interest in lyo-liquid and liquid-liquid drug delivery, highlighting some of the current unmet needs in this space. Following this, they discuss how platform technologies, such as electromechanical drives, may help address these unmet needs.
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