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DUAL CHAMBER

INDUSTRIALISATION
INNOVATION AND AUTOMATION REUNITED – ENABLING SCALABLE FINAL ASSEMBLY FOR CARTRIDGE-BASED AUTOINJECTORS
Using SHL Medical's Reunite™ dual-chamber autoinjector and SHL Advantec's AOU™ assembly machine platform as a case study, Christy Chen and Alberto Flores explore the critical synergy between flexible automation architecture and expert final assembly services.
DUAL CHAMBER
DE-RISKING A NOVEL VALVE COMPONENT FOR USE WITH STANDARD SYRINGE AND AUTOINJECTOR PLATFORMS
Marc Flippe and Sophie Lelias introduce a novel valve component designed to enable dual-chamber functionality within standard syringe and autoinjector platforms. Developed through a comprehensive modelling and development framework, the BD dual-injection syringe system provides a scalable solution to dual-chamber injection that reduces the burden of change by preserving compatibility with established container formats and device architectures.
Testing Prefilled Syringes to ISO 11040
INJECTION
Landon Goldfarb
Instron
Testing Prefilled Syringes to ISO 11040
Instron's Landon Goldfarb talks through ISO 11040, a testing standard that addresses the design and functional properties of prefilled syringes.
AUTOINJECTOR TECHNOLOGY FOR AUTOMATIC MICROPARTICLE SUSPENSION AND INJECTION
INJECTION
Girum Yemane-Tekeste
Kindeva
AUTOINJECTOR TECHNOLOGY FOR AUTOMATIC MICROPARTICLE SUSPENSION AND INJECTION
Girum Yemane-Tekeste and Stephen Leslie share how Kindeva is building on its experience and history of innovation to develop an enabling technology for injectable microparticles and then evaluating it through proof-of-principle testing.
Dual-Chamber Syringes, New Partnerships, and Speed-to-Market Pressures Shape 2026
VIDEO
John Merhige
Credence MedSystems
Dual-Chamber Syringes, New Partnerships, and Speed-to-Market Pressures Shape 2026
John Merhige outlines his key themes shaping drug delivery in 2026: new momentum from a dual-chamber syringe fill-finish collaboration, a newly announced commercial supply agreement with a major global pharma company, and growing pressure to deliver increasingly complex molecules faster and more efficiently.
TRENDS FOR 2026
EXPERT VIEW
Tom Oakley
TRENDS FOR 2026
A new reality is forming as we enter 2026 – it will not be “business as usual”. Geopolitical forces in the largest market for pharmaceuticals, the US, are likely to mean substantial changes. Here, Tom Oakley and Alex Vasiev cover those changes, the incretin juggernaut and the march of technical progress with “minitablet” dispensers, large-volume injectors and dual-chamber devices.
THE PLATFORM PARADOX: DEVICE DEVELOPMENT CHALLENGES WITHIN FAST EVOLVING DRUG DISCOVERY PIPELINES
EXPERT VIEW
Tim Quigg
THE PLATFORM PARADOX: DEVICE DEVELOPMENT CHALLENGES WITHIN FAST EVOLVING DRUG DISCOVERY PIPELINES
Tim Quigg, Mariam Al-Amari and Joel Gresham discuss how to enable high-dose delivery for novel biologics, using ex vivo and in silico approaches to accelerate drug-device development and improve device performance, thus de-risking projects and saving costs.
ADOPTION OF SUSTAINABILITY PRACTICES WITHIN SUBCUTANEOUS DRUG DELIVERY: INDUSTRY INSIGHTS
PHARMA VIEW
Conor O'Neill
GSK
ADOPTION OF SUSTAINABILITY PRACTICES WITHIN SUBCUTANEOUS DRUG DELIVERY: INDUSTRY INSIGHTS
Conor O’Neill (GSK), Duncan Paterson (AstraZeneca) and Dr Monica Adams (GSK) come together to discuss a recent study conducted by the Subcutaneous Drug Development & Delivery Consortium among its member organisations, digging into the pharmaceutical industry’s progress and priorities when it comes to improving the environmental impact of subcutaneous medicines.
Interview: Making Dual-Chamber Systems a Viable Alternative
INTERVIEW
Laxman Halleppanavar
Credence MedSystems
Interview: Making Dual-Chamber Systems a Viable Alternative
In this exclusive interview, Laxman Halleppanavar and Guy Furness discuss industry trends and challenges with injectable delivery, and how Credence MedSystems' dual-chamber devices provide solutions to address those challenges. Mr Halleppanavar goes into details of Credence’s role in this increasingly important sector of the drug delivery market, explaining the company’s approach to device design, development and overcoming the barriers posed by supply chain management.
HIGH SPEED LASER ASSEMBLY – FLEXIBLE MACHINE CONCEPTS WITH FULL LASER INTEGRATION
INDUSTRIALISATION
Matthias Müller
Contexo
HIGH SPEED LASER ASSEMBLY – FLEXIBLE MACHINE CONCEPTS WITH FULL LASER INTEGRATION
Matthias Müller discusses the advantages of including laser technology in drug delivery device manufacturing, covering the various ways in which this technology can be applied and used to provide efficient, cost-effective and clean processes at high throughput rates.
IMPROVING THE SELF-ADMINISTRATION OF LYO- AND LIQUID-LIQUID FORMULATIONS
DUAL CHAMBER
Bjørn Knud Andersen
Phillips Medisize
IMPROVING THE SELF-ADMINISTRATION OF LYO- AND LIQUID-LIQUID FORMULATIONS
Bjørn Andersen and Iain Simpson explore the factors contributing to interest in lyo-liquid and liquid-liquid drug delivery, highlighting some of the current unmet needs in this space. Following this, they discuss how platform technologies, such as electromechanical drives, may help address these unmet needs.
TWO INTO ONE: SOLVING COMPLEX DRUG DELIVERY PROBLEMS WITH DUAL-CHAMBER CONTAINMENT SOLUTIONS
DUAL CHAMBER
Enrico Barichello
Stevanato Group
TWO INTO ONE: SOLVING COMPLEX DRUG DELIVERY PROBLEMS WITH DUAL-CHAMBER CONTAINMENT SOLUTIONS
Enrico Barichello and Valerio Ravazzolo describe how dual-chamber solutions ensure isolation, integrity and safety for managing lyophilised and liquid drugs. With innovative and customisable designs, these technologies improve drug delivery, reduce contamination risks and simplify complex therapies, addressing the evolving needs of both pharmaceutical industry and patients.
ADVANCING LYOPHILISED DRUG DELIVERY WITH REUNITE™: RECONSTITUTION MADE SIMPLE
DUAL CHAMBER
Dr Nina Fetz
SHL Medical
ADVANCING LYOPHILISED DRUG DELIVERY WITH REUNITE™: RECONSTITUTION MADE SIMPLE
Dr Nina Fetz introduces SHL Medical's Reunite®, the first and only commercialised dual-chamber cartridge, three-step autoinjector featuring the company’s Needle Isolation Technology. With automated reconstitution, Reunite enables reliable self-injection of lyophilised formulations, supporting home-based care models.
BEYOND THE BARREL: A DUAL-CARTRIDGE IMPROVEMENT TO TRADITIONAL DUAL-CHAMBER DEVICES
DUAL CHAMBER
Dr Brent Buchine
Windgap Medical
BEYOND THE BARREL: A DUAL-CARTRIDGE IMPROVEMENT TO TRADITIONAL DUAL-CHAMBER DEVICES
Dr Brent Buchine explores how Windgap Medical’s devices transform dual-chamber systems with a modular, scalable and remarkably simple approach to reconstitution and complex drug delivery.
FROM HOSPITAL TO HOME HEALTHCARE: ADVANCES IN LYOPHILISED PRODUCT DELIVERY
EXPERT VIEW
Edward Trappler
FROM HOSPITAL TO HOME HEALTHCARE: ADVANCES IN LYOPHILISED PRODUCT DELIVERY
Edward Trappler, Denise Miller and Michael Thomas discuss the challenges for lyophilised products and consider the role of dual-chamber devices in simplifying reconstitution, particularly for at-home healthcare products, and go on to look at how future advances in delivery devices are providing safe solutions for self-administration while improving patient adherence.
POWDER TO THE PEOPLE: ACCELERATING ACCESS TO LYOPHILISED THERAPIES
EXPERT VIEW
Kristien De Clercq
POWDER TO THE PEOPLE: ACCELERATING ACCESS TO LYOPHILISED THERAPIES
Kristien De Clercq and Dr Alex Vasiev discuss the challenges and recent advances in drying and reconstitution technologies, as well as how, while dual-chamber primary packaging offers a potential solution for simplifying reconstitution, it remains underused due to usability concerns and a prevailing industry preference for vial-based lyophilisation over alternative drying methods such as spray drying and powder filling.
ADVANCING LYOPHILISED DRUG DEVELOPMENT IN DUAL-CHAMBER SYSTEMS
DUAL CHAMBER
Dr Markus Neumeier
Vetter Pharma
ADVANCING LYOPHILISED DRUG DEVELOPMENT IN DUAL-CHAMBER SYSTEMS
Dr Markus Neumeier details the lyophilisation process and the range of elements that need to be examined for a dual-chamber system undergoing freeze-drying, while also laying out the quality control processes to conduct when transitioning from the laboratory to industrial-scale operations.
Early Insight: RETHINKING DUAL-CHAMBER SYRINGES: A LATERAL APPROACH TO FASTER, SAFER RECONSTITUTION
EARLY INSIGHT
Eric Sugalski
Ampulis
Early Insight: RETHINKING DUAL-CHAMBER SYRINGES: A LATERAL APPROACH TO FASTER, SAFER RECONSTITUTION
Eric Sugalski examines the limitations of current concentric dual-chamber syringe designs and explores a novel, lateral-chamber approach from Ampulis – the Ampulis Reconstitution Syringe.
Early Insight: DuoVIAL<sup>®</sup> – PROTECT, MIX AND DELIVER
EARLY INSIGHT
Gareth Pearce
Pacifi Ltd
Early Insight: DuoVIAL® – PROTECT, MIX AND DELIVER
Gareth Pearce introduces Pacifi's DuoVIAL® primary packaging technology for topical lyophilised formulations – a minimalist dual-chamber drug delivery system that enables safer, easier and more cost-effective reconstitution, while retaining the proven materials, formats and filling processes well established in the pharmaceutical sector.
DELIVERING COMPLEXITY: DEVICE CONSIDERATIONS FOR TWO-COMPONENT INJECTABLE FORMULATIONS
EXPERT VIEW
María FM Balson
DELIVERING COMPLEXITY: DEVICE CONSIDERATIONS FOR TWO-COMPONENT INJECTABLE FORMULATIONS
María FM Balson weighs up strengths and limitations when developing devices for lyophilised injectables, exploring their growing demand and the impacts of formulation, device type and design on the feasibility for bringing a device to market to deliver these essential therapies.
Interview: PDA Miniverse and Trends in Injectable Drug Delivery
INTERVIEW
Mathias Romacker
Kymanox
Interview: PDA Miniverse and Trends in Injectable Drug Delivery
In this exclusive interview, Mathias Romacker and Evan Edwards talk with ONdrugDelivery’s Guy Furness about the upcoming inaugural PDA Miniverse conference in Indianapolis, and the topics and trends currently being felt across the injectable drug delivery industry.
COMPANY SHOWCASE: VETTER PHARMA
INJECTION
Vetter Pharma
COMPANY SHOWCASE: VETTER PHARMA
Vetter is a CDMO that offers services for pharma and biotech firms of all sizes and locations and holds numerous patents, including technologies for protection against tampering and counterfeiting. Its expertise ranges from lyophilisation (freeze-drying) to siliconisation and more.
DESIGNING FOR SUCCESS: CHOOSING THE RIGHT PRIMARY DRUG CONTAINER FOR PREFILLED DELIVERY DEVICES
DUAL CHAMBER
Dr Brent Buchine
Windgap Medical
DESIGNING FOR SUCCESS: CHOOSING THE RIGHT PRIMARY DRUG CONTAINER FOR PREFILLED DELIVERY DEVICES
Brent Buchine and Jason Durkin reflect on the motivations and lessons from Windgap’s journey to design patient-centric, prefilled autoinjectors around custom and standard primary drug containers.
CAPA VALVE’S PATENTED TECHNOLOGY TRANSFORMS ANY SYRINGE INTO A DCD
EARLY INSIGHT
Dr Phil Green
Capa Valve
CAPA VALVE’S PATENTED TECHNOLOGY TRANSFORMS ANY SYRINGE INTO A DCD
Phil Green, Dale Charlton and Kevin Abbott introduce Capa Valve’s novel valve system for converting standard syringes into prefilled dual-chamber devices, capable of simplifying and improving the delivery of liquid-liquid and liquid-powder drug products, including reconstitution of lyophilised powders.
INTERVIEW: DOUG BRYANS, BRYLLAN & JOHN MERHIGE, CREDENCE
INTERVIEW
Dr Doug Bryans
Bryllan
INTERVIEW: DOUG BRYANS, BRYLLAN & JOHN MERHIGE, CREDENCE
Douglas Bryans and John Merhige discuss the changing needs of drug developers around novel dual-chamber and ready-to-use drug delivery devices, capacity and the delivery of complete solutions from CDMOs and device developers, anchored around the recently announced partnership between Credence MedSystems and Bryllan to provide these critical services.
IN THE THICK OF IT: ACCELERATING THE MIXING AND DELIVERY OF HIGH-VISCOSITY INJECTABLES
DUAL CHAMBER
Dr Brent Buchine
Windgap Medical
IN THE THICK OF IT: ACCELERATING THE MIXING AND DELIVERY OF HIGH-VISCOSITY INJECTABLES
Brent Buchine, Miriam Silton, Jameson Woods and Andrew Ryan explore how the combination of gas power and a side-by-side cartridge configuration increases the working viscosity range for the mixing and delivery of complex injectable formulations.
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