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EXPERT VIEW

THE IRONIES OF AUTOMATION: LESSONS FOR REMOTE PATIENT MONITORING
EXPERT VIEW
Dan Lock
THE IRONIES OF AUTOMATION: LESSONS FOR REMOTE PATIENT MONITORING
Dan Lock considers how to overcome potential pitfalls and make the most of remote patient monitoring for the benefit of both patient care and clinical trials.
MODIFIED-RELEASE MICROSPHERES: MAXIMISING COATING INTEGRITY AND OPTIMISING RELEASE
EXPERT VIEW
Dr Jonathan Cape
MODIFIED-RELEASE MICROSPHERES: MAXIMISING COATING INTEGRITY AND OPTIMISING RELEASE
Jonathan Cape discusses development considerations and workflows to select optimal enteric coat weights for modified release microspheres – balancing performance considerations with API stability and the excipient burden to patients.
INCREASE PRODUCTION SUCCESS THROUGH TABLET DESIGN TECHNIQUES
EXPERT VIEW
Richard Ball
INCREASE PRODUCTION SUCCESS THROUGH TABLET DESIGN TECHNIQUES
Richard Ball considers the important features of tablet design and discusses its importance to the mass production of tablets.
HARD CAPSULES: A HOLISTIC APPROACH FOR ORAL DRUG DELIVERY AND FORMULATION
EXPERT VIEW
Dr Jnanadeva Bhat
HARD CAPSULES: A HOLISTIC APPROACH FOR ORAL DRUG DELIVERY AND FORMULATION
Jnanadeva Bhat and Manali Dalvi discuss how advances in capsule technology as an oral drug delivery method have opened up new avenues for the development of more effective and patient-friendly drugs.
ENSURING PATIENT SAFETY AMIDST MEDICAL DEVICE REGULATION DELAYS WITH PMS
EXPERT VIEW
Timothy Bubb
ENSURING PATIENT SAFETY AMIDST MEDICAL DEVICE REGULATION DELAYS WITH PMS
Timothy Bubb discusses the five steps to setting up an effective post-market surveillance process.
DESIGNING FOR USABILITY IN EMERGENCY-USE COMBINATION PRODUCTS
EXPERT VIEW
Thomas James
DESIGNING FOR USABILITY IN EMERGENCY-USE COMBINATION PRODUCTS
Thomas James highlights the importance of early user engagement, as well as continuous refinement of information and workflow design, for efficient development of drug-device combination products for emergency use.
TACKLING DESIGN CHALLENGES IN EMERGENCY-USE AUTOINJECTORS
EXPERT VIEW
John Burke
TACKLING DESIGN CHALLENGES IN EMERGENCY-USE AUTOINJECTORS
John Burke considers the challenges that manufacturers need to overcome when designing emergency-use autoinjectors.
STRATEGIES FOR TEST METHOD VALIDATION OF DRUG DELIVERY PLATFORMS
EXPERT VIEW
Deepu Asok
STRATEGIES FOR TEST METHOD VALIDATION OF DRUG DELIVERY PLATFORMS
Deepu Asok discusses the importance of test method validation for drug-device combination product development and how a common mistake is to design the validation process for a specific device rather than to accommodate the potential variety of a device platform.
MITIGATING CONTAINER CLOSURE INTEGRITY CHALLENGES FOR INJECTABLES
EXPERT VIEW
Eugene Polini
MITIGATING CONTAINER CLOSURE INTEGRITY CHALLENGES FOR INJECTABLES
Eugene Polini discusses the importance of container closure for the parenteral drug market, including some of the consequences of compromised container closure and what steps manufacturers can take to ensure that primary packaging systems remain sealed for a product’s entire shelf life.
RETHINKING PLASTIC: HOW ECO-FRIENDLY DESIGN IS DRIVING SUSTAINABLE CHANGE
EXPERT VIEW
Giorgio Sardo
RETHINKING PLASTIC: HOW ECO-FRIENDLY DESIGN IS DRIVING SUSTAINABLE CHANGE
Giorgio Sardo discusses sustainable material selection and the results of tests comparing the performance of sustainable bio-based plastic resins with their fossil-based equivalents.
DESIGNING SUSTAINABILITY INTO PHARMACEUTICAL DEVICES
EXPERT VIEW
Will Davies
DESIGNING SUSTAINABILITY INTO PHARMACEUTICAL DEVICES
Will Davies discusses in detail how to address the challenges of designing sustainability into pharmaceutical devices.
SUSTAINABILITY IN DRUG DELIVERY: HOW DO WE GET THERE?
EXPERT VIEW
Tim Wooller
SUSTAINABILITY IN DRUG DELIVERY: HOW DO WE GET THERE?
Tim Wooller discusses the urgent need to transition away from disposable models of drug delivery device design and move towards reusables, providing insights into the reasons why and the methods by which this can be achieved.
IMPROVING RECYCLABILITY IN DRUG DELIVERY
EXPERT VIEW
Julien Tremblin
IMPROVING RECYCLABILITY IN DRUG DELIVERY
Julien Tremblin looks at the recyclability challenges facing the drug delivery market and considers how companies can enhance the recyclability of their packaging and devices.
DUE DILIGENCE – THE KEY TO SUCCESS IN DRUG DELIVERY DEVICE SELECTION
EXPERT VIEW
Matt Jones
DCA
DUE DILIGENCE – THE KEY TO SUCCESS IN DRUG DELIVERY DEVICE SELECTION
Matt Jones and Rob Veasey consider the process of matching the drug with the right delivery device and look at the importance of due diligence when “licensing in” technology.
CONSIDERATIONS WHEN SWITCHING FROM CURRENT pMDI PROPELLANTS TO NEW LOWER-GWP PROPELLANTS
EXPERT VIEW
Mark Parry
CONSIDERATIONS WHEN SWITCHING FROM CURRENT pMDI PROPELLANTS TO NEW LOWER-GWP PROPELLANTS
Mark Parry discusses the considerations that need to be made when switching from current pressurised metered dose inhaler propellants to new alternatives with lower global warming potential, including formulation, regulatory and analytical standpoints.
THE NEXT GENERATION OF MICRONEEDLES: HARNESSING A BILLION YEARS OF EVOLUTION
EXPERT VIEW
Dr Gabriel Villar
THE NEXT GENERATION OF MICRONEEDLES: HARNESSING A BILLION YEARS OF EVOLUTION
Gabriel Villar and Ethan Miller consider examples of nature’s solutions to four challenges faced by microneedles for drug delivery. For each challenge, the authors explain how a natural organism has tackled it and what lessons may be directly applied to microneedle design.
OVERCOMING CHALLENGES WHEN DEVELOPING OLIGONUCLEOTIDES FOR OPHTHALMIC DRUGS
EXPERT VIEW
Dr Shiyan Chen
OVERCOMING CHALLENGES WHEN DEVELOPING OLIGONUCLEOTIDES FOR OPHTHALMIC DRUGS
Shiyan Chen and Binbin Tian discuss the use of oligonucleotides for ophthalmic applications, including their potential uses, advantages, challenges and difficulties when it comes to pharmacokinetic and drug metabolism studies.
TOPICAL DRUG ADMINISTRATION FOR THE POSTERIOR SEGMENT
EXPERT VIEW
Dr David Bingaman
TOPICAL DRUG ADMINISTRATION FOR THE POSTERIOR SEGMENT
David Bingaman explores the potential benefits of topical administration for diseases affecting the posterior segment of the eye.
BEYOND THE EYEDROPPER BOTTLE – THREE WAYS TO IMPROVE ADHERENCE
EXPERT VIEW
Dr Nathan Wilkinson
BEYOND THE EYEDROPPER BOTTLE – THREE WAYS TO IMPROVE ADHERENCE
Nathan Wilkinson, Catherine Wyman and Matt Parker discuss the future outlook of ophthalmic drug delivery beyond the traditional eyedropper bottle, including new delivery technologies, sustained-release therapeutics and digital healthcare applications.
A SIGHT FOR SORE EYES: CHALLENGES & INNOVATIONS IN OPHTHALMIC DRUG DELIVERY
EXPERT VIEW
Dr Ethan Miller
A SIGHT FOR SORE EYES: CHALLENGES & INNOVATIONS IN OPHTHALMIC DRUG DELIVERY
Ethan Miller and Kristien De Clercq discuss recent advancements and current challenges in the field of ophthalmology, including the trend towards preservative-free multidose delivery systems, delivering smaller topical volumes with increased drug efficacy, slow-release injections for delivery to the posterior of the eye and the exciting field of gene therapy.
EXTRACTABLES/LEACHABLES TESTING CONSIDERATIONS FOR SINGLE-USE SYSTEMS
EXPERT VIEW
Sandi Schaible
EXTRACTABLES/LEACHABLES TESTING CONSIDERATIONS FOR SINGLE-USE SYSTEMS
Sandi Schaible discusses testing considerations for extractables and leachables along with the regulatory environment for single-use systems.
CONNECTED DRUG DELIVERY DEVICES: BENEFITS AND CYBERSECURITY
EXPERT VIEW
João Budzinski
CONNECTED DRUG DELIVERY DEVICES: BENEFITS AND CYBERSECURITY
João Budzinski discusses the benefits of connected drug delivery devices and the importance of cybersecurity when developing them, including the threats, key considerations and potential solutions.
EXPANDING THE DESIGN OF CHARACTERISATION STUDIES FOR ACCURATE HANDLING-ERROR ASSESSMENT
EXPERT VIEW
Dr Yannick Baschung
EXPANDING THE DESIGN OF CHARACTERISATION STUDIES FOR ACCURATE HANDLING-ERROR ASSESSMENT
Yannick Baschung discusses the importance of a comprehensive and accurate assessment of patient handling errors when it comes to inhaled product development.
THE INFLUENCE OF UNCERTAINTY ON CHEMICAL CHARACTERISATION
EXPERT VIEW
James Silk
THE INFLUENCE OF UNCERTAINTY ON CHEMICAL CHARACTERISATION
James Silk discusses the importance of accounting for uncertainty when characterising the extractables profile of a medication, with particular reference to the ISO 10993 standard.
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