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NASAL

EXPERT VIEW
NASAL DRUG DELIVERY: OVERCOMING CHALLENGES WITH A ROBUST PLATFORM STRATEGY
Richard Johnson explores the changing nasal delivery landscape, highlighting challenges in nasal drug formulation and potential methods to overcome them.
NASAL
UNLOCKING THE POTENTIAL OF INTRANASAL DRUG DELIVERY
Allan Houston, Marcel Sachs and Heiko Rolland discuss the healthcare potential of intranasal drug delivery systems and the necessary steps for bringing these solutions to market. 
SPRAY DELIVERY: TARGETING PATIENT NEEDS AND EXPECTATIONS WITH PRECISION
PULMONARY
Gladys Corrons-Bouis
Eveon
SPRAY DELIVERY: TARGETING PATIENT NEEDS AND EXPECTATIONS WITH PRECISION
Gladys Corrons-Bouis and Cyril Le Loc’h discuss the use of spray delivery for precise targeting of patient medication.
CHALLENGES BESIDES DRUG TARGETING – REGULATORY HURDLES FOR MULTIDOSE NASAL SPRAYS
NASAL
Dr Marie-Christine Klein
URSATEC
CHALLENGES BESIDES DRUG TARGETING – REGULATORY HURDLES FOR MULTIDOSE NASAL SPRAYS
Marie-Christine Klein,  Andreas Bilstein and Rouven Kraus, discuss recent regulatory changes affecting drug-device combination products, using the example of a multidose nasal spray.
BENEFITS OF INNOVATIVE COMPRESSED GAS-POWERED INTRANASAL DRUG DELIVERY DEVICES
PULMONARY
Albie Lavin
Picocyl
BENEFITS OF INNOVATIVE COMPRESSED GAS-POWERED INTRANASAL DRUG DELIVERY DEVICES
Albie Lavin discusses the exciting potential of propellant-driven systems for intranasal delivery, and how Picocyl’s Pico-Cylinders provide the ideal mechanism to take advantage of this potential.
TAKING A DRUG TO FIRST-IN-HUMAN TRIALS IN A BESPOKE DEVICE FOR TARGETED INTRANASAL DELIVERY
EXPERT VIEW
Dr Mark Allen
TAKING A DRUG TO FIRST-IN-HUMAN TRIALS IN A BESPOKE DEVICE FOR TARGETED INTRANASAL DELIVERY
Mark Allen, Andrew Fiorini and Shai Assia discuss the need to develop delivery devices early when formulating nasally delivered drugs for systemic and local action, and a method by which the route to clinic can be made easier, faster and cheaper. 
SPRAYTEC LASER DIFFRACTION: ROBUST, REPRODUCIBLE DROPLET SIZE DATA
PULMONARY
Dr Anne Virden
Malvern Panalytical
SPRAYTEC LASER DIFFRACTION: ROBUST, REPRODUCIBLE DROPLET SIZE DATA
Anne Virden discusses the benefits and applications of Malvern Panalytical's Spraytec laser diffraction system for the measurement of spray particles and droplets.
INTERVIEW: RDD EUROPE 2023 REVIEW & RDD 2024 PREVIEW
CONFERENCE SHOWCASE
RDD
INTERVIEW: RDD EUROPE 2023 REVIEW & RDD 2024 PREVIEW
Respiratory Drug Delivery talks with ONdrugDelivery, reviewing highlights of the successful RDD Europe 2023 event, which took place in Antibes, France last May, then describing what’s ahead for RDD 2024, which will take place in Tuscon, AZ, US, next May, including some of the key upcoming deadlines for participants.
CUSTOMISABLE MESH NEBULISER PLATFORMS: VALUE IN COMBINATION PRODUCT DEVELOPMENT
PULMONARY
Edgar Hernan Cuevas Brun
HCmed Innovations
CUSTOMISABLE MESH NEBULISER PLATFORMS: VALUE IN COMBINATION PRODUCT DEVELOPMENT
Edgar Hernan Cuevas Brun and Yuan-Ming Hsu look at the advantages of customisable nebuliser platforms for new combination products.
DEVELOPING AN INHALABLE FORMULATION OF THE FIRST GENERATIVE AI DRUG
PHARMA INSIGHT
Brita Belli
Insilico Medicine
DEVELOPING AN INHALABLE FORMULATION OF THE FIRST GENERATIVE AI DRUG
Brita Belli introduces Insilico Medecine’s inhalable formulation of its AI-designed therapy for the treatment of idiopathic pulmonary fibrosis, its progression through clinical trials and the company’s approach to generative AI in the pharmaceutical space more broadly.
ACCELERATING THE GO-TO-MARKET OF NASAL COMBINATION PRODUCTS WITH INTEGRATED SOLUTIONS
NASAL
Séverine Duband
Nemera
ACCELERATING THE GO-TO-MARKET OF NASAL COMBINATION PRODUCTS WITH INTEGRATED SOLUTIONS
Séverine Duband and Audrey Chandra discuss emerging trends in the ear, nose and throat market and how Nemera can assist in bringing new devices to market.
NAVIGATING THE CHALLENGES OF BRINGING INTRANASAL DRUG FORMULATIONS & DEVICES TO PATIENTS
NASAL
Joe Neale
Recipharm
NAVIGATING THE CHALLENGES OF BRINGING INTRANASAL DRUG FORMULATIONS & DEVICES TO PATIENTS
Joe Neale and Ross Errington explore the obstacles and opportunities facing the intranasal drug delivery market and how manufacturers can overcome them by harnessing innovative platforms like Unidose® Xtra.
THE APPLICATION DIVERSITY OF METERED PUMP-BASED SOFT MIST DEVICES
PULMONARY
Dr Marie-Christine Klein
URSATEC
THE APPLICATION DIVERSITY OF METERED PUMP-BASED SOFT MIST DEVICES
Marie-Christine Klein, Andreas Bilstein and Caroline Hoffmann discuss the underlying techniques involved in the use of metered pump-based soft mist devices and their application diversity.
THE POTENTIAL AND THE CHALLENGES OF NASAL VACCINATION
NASAL
Dr Julie Suman
Aptar Pharma
THE POTENTIAL AND THE CHALLENGES OF NASAL VACCINATION
Julie Suman and Nektaria Karavas discuss the challenges and opportunities of intranasal vaccination – showcasing current understanding for both liquid and powder products. Experimental studies highlight critical issues, the performance of commercially available devices and developments in formulation practice.
STEPS TO SUCCESS IN NOSE-TO-BRAIN DRUG DELIVERY
NASAL
Reenal Gandhi
Aptar Pharma
STEPS TO SUCCESS IN NOSE-TO-BRAIN DRUG DELIVERY
Reenal Gandhi and Gemma Budd consider the multiple hurdles associated with developing nasal drug delivery solutions, current understanding of the associated biology and the advantages of alternative device designs and state-of-the-art formulation practice.
THE INFLUENCE OF UNCERTAINTY ON CHEMICAL CHARACTERISATION
EXPERT VIEW
James Silk
THE INFLUENCE OF UNCERTAINTY ON CHEMICAL CHARACTERISATION
James Silk discusses the importance of accounting for uncertainty when characterising the extractables profile of a medication, with particular reference to the ISO 10993 standard.
ENGINEERING EXPERTISE: DESIGN FOR EXCELLENCE
INDUSTRIALISATION
Drew Jelgerhuis
Scherdel Medtec North America
ENGINEERING EXPERTISE: DESIGN FOR EXCELLENCE
Drew Jelgerhuis looks at how a design-for-excellence (DFX) systematic approach can help manufacturers achieve their objectives.
TAKING THE STING OUT OF VACCINES
EXPERT VIEW
Dr Heather Jameson
TAKING THE STING OUT OF VACCINES
Heather Jameson, Juliette Ngan and Omar Shah discuss the potential advantages and challenges of intranasal and inhaled vaccines in the context of global respiratory pandemics.
SOLVING COMPLEX FORMULATION & DELIVERY CHALLENGES FOR INTRANASAL DRUGS
EXPERT VIEW
Dr Paul Kippax
SOLVING COMPLEX FORMULATION & DELIVERY CHALLENGES FOR INTRANASAL DRUGS
Paul Kippax discusses the analytical techniques used for in vitro characterisation of nasal sprays, and how their use can accelerate and de-risk both innovator and generic nasal drug development.
NASAL DELIVERY – A GALAXY NOT SO FAR AWAY… A BRIEF MARKET HISTORY OF THE NASAL DELIVERY LANDSCAPE
EXPERT VIEW
Mark Ignaczak
NASAL DELIVERY – A GALAXY NOT SO FAR AWAY… A BRIEF MARKET HISTORY OF THE NASAL DELIVERY LANDSCAPE
Mark Ignaczak provides an insight into the history of nasal drug delivery and looks at the advantages of the nasal delivery route.
HOLISTIC DEVELOPMENT & INDUSTRIALISATION OF DRUG DELIVERY DEVICES & COMBINATION PRODUCTS
INDUSTRIALISATION
Mark Tunkel
Nemera
HOLISTIC DEVELOPMENT & INDUSTRIALISATION OF DRUG DELIVERY DEVICES & COMBINATION PRODUCTS
Mark Tunkel and Niyati Sapatnekar discuss Nemera’s holistic approach to development and industrialisation.
A GAME CHANGER FOR HIGH-RISK MEDICATIONS VIA AN INTRANASAL DELIVERY PLATFORM
CONNECTIVITY
Marcel Botha
Aero Pump
A GAME CHANGER FOR HIGH-RISK MEDICATIONS VIA AN INTRANASAL DELIVERY PLATFORM
Marcel Botha, Andreas Bilstein, Houssam Elghobary and Rouven Kraus discuss the benefits of the Validose digital health platform for the safe delivery of high-value and/or high-risk products.
ADVANCEMENTS AND EVOLUTION OF POWER SOURCES IN DRUG DELIVERY
INJECTION
Bill Welch
Picocyl
ADVANCEMENTS AND EVOLUTION OF POWER SOURCES IN DRUG DELIVERY
William Welch considers the evolution of compressed gas alternatives to spring power for single-use drug delivery devices.
NANOTECHNOLOGY: A NEXT-GENERATION TOOL FOR PULMONARY & NASAL DELIVERY
EXPERT VIEW
Frédérique Bordes-Picard
NANOTECHNOLOGY: A NEXT-GENERATION TOOL FOR PULMONARY & NASAL DELIVERY
Frédérique Bordes-Picard looks at the role of nanotechnology in the nasal and pulmonary routes of drug delivery and explains how nanoparticle explains how nanoparticle solutions could transform patient comfort and compliance.
WAITING WITH BATED BREATH – WHAT’S IN STORE FOR 2022
EXPERT VIEW
Rob Udale
WAITING WITH BATED BREATH – WHAT’S IN STORE FOR 2022
Rob Udale and Heather Jameson discuss the exciting developments taking place in the design of inhalation devices and share their predictions for the top five inhalation trends to watch as 2022 unfolds, and beyond.
NOSE-TO-BRAIN DRUG ADMINISTRATION AND A NOVEL APPROACH WITH AN OLD FAMILIAR
NASAL
Dr Marie-Christine Klein
Aero Pump
NOSE-TO-BRAIN DRUG ADMINISTRATION AND A NOVEL APPROACH WITH AN OLD FAMILIAR
Marie-Christine Klein, Andreas Bilstein and Rouven Kraus look at the advantages of the nose-to-brain route and soft mist nasal sprays for drug administration.
INTERVIEW: JON LENN & JON VOLMER, MEDPHARM
INTERVIEW
Dr Jon Lenn
MedPharm
INTERVIEW: JON LENN & JON VOLMER, MEDPHARM
Jon Lenn and Jon Volmer talked with Guy Furness about the importance of nasal modelling, focusing on MedPharm’s own nasal cavity modelling technology, MedCast, its unique characteristics and benefits and the value it brings to the company’s offering for nasally delivered products.
AN INVITATION TO PARTICIPATE IN STANDARDISATION OF PARTICLE MEASUREMENTS FOR PHARMACEUTICALS
EXPERT VIEW
Dr Caterina Minelli
AN INVITATION TO PARTICIPATE IN STANDARDISATION OF PARTICLE MEASUREMENTS FOR PHARMACEUTICALS
Caterina Minelli discusses the importance of co-operation between metrology institutes and the pharmaceutical industry in the pursuit of improving analytical techniques and standards for the characterisation of particle attributes in drug development.
NASAL DELIVERY SYSTEM EXPANDS PUBLIC AND PATIENT ACCESS TO NALOXONE TO MITIGATE THE OPIOID OVERDOSE EPIDEMIC
NASAL
Dr Todd Pizitz
CounterAct
NASAL DELIVERY SYSTEM EXPANDS PUBLIC AND PATIENT ACCESS TO NALOXONE TO MITIGATE THE OPIOID OVERDOSE EPIDEMIC
Todd D Pizitz and Donald R Mealing discuss the ongoing US opioid epidemic, the CounterAct cap containing a single dose of naloxone to be attached to prescribed opioids, and a recent pilot market study done to gauge public enthusiasm for this life-saving technology.
ADDRESSING SYSTEMIC DELIVERY WITH A UNIT-DOSE NASAL SPRAY
NASAL
Audrey Chandra
Nemera
ADDRESSING SYSTEMIC DELIVERY WITH A UNIT-DOSE NASAL SPRAY
Audrey Chandra and Raphaële Audibert discuss the benefits of a unit-dose nasal spray for rapid treatment in an emergency.
BREACHING THE BLOOD-BRAIN-BARRIER WITH PARTICLE-BASED NASAL DELIVERY SYSTEMS
NASAL
Tom French
3P Innovation
BREACHING THE BLOOD-BRAIN-BARRIER WITH PARTICLE-BASED NASAL DELIVERY SYSTEMS
Tom French talks about the advantages of the nasal drug delivery route and crossing the blood-brain-barrier to treat central nervous system diseases.
ADDRESSING THE CHALLENGES OF NASAL BIOTHERAPEUTIC DRUG DELIVERY
EXPERT VIEW
Robert Lee
ADDRESSING THE CHALLENGES OF NASAL BIOTHERAPEUTIC DRUG DELIVERY
Robert Lee discusses the benefits of administering drugs to the nasal cavity, as well as the main challenges in formulation for this route and the strategies that can be applied to overcome them.
IMPROVING IN VITRO TEST METHODS FOR NASAL DRUG PRODUCTS
NASAL
Mark Copley
Copley Scientific
IMPROVING IN VITRO TEST METHODS FOR NASAL DRUG PRODUCTS
Mark Copley and Anna Sipitanou look at how in vitro testing is being refined for greater repeatability to maximise its value as a low-cost tool for product development, including an assessment of the role of automation in improving the sensitivity of in vitro testing.
DELIVERING ON THE PROMISES OF INTRANASAL VACCINATION
NASAL
Dr Julie Suman
Aptar Pharma
DELIVERING ON THE PROMISES OF INTRANASAL VACCINATION
Julie Suman and Nektaria Karavas review intranasal delivery as a method of vaccine administration and consider the challenges and benefits of intranasal delivery.
SUCCESSFULLY BALANCING THE NEEDS OF THE PLANET WITH THE NEEDS OF THE PATIENT
SUSTAINABILITY
Julien Storz
Aptar Pharma
SUCCESSFULLY BALANCING THE NEEDS OF THE PLANET WITH THE NEEDS OF THE PATIENT
Christophe Marie, Taylor Price and Julien Storz chart the commitments and progress made to date by Aptar in achieving its sustainability targets. The authors also provide examples of integrated, circular economy initiatives undertaken by Aptar Pharma at a product solution level and comment on concrete commitments that can be made to further progress towards sustainability.
THE CRITICAL ROLE OF TRAINING IN THE USE OF NASAL RESCUE THERAPIES
NASAL
Tim McLeroy
Noble
THE CRITICAL ROLE OF TRAINING IN THE USE OF NASAL RESCUE THERAPIES
Tim McLeroy discusses the role of nasally administered rescue treatments in preventing deaths from opioid overdose or misuse – highlighting the importance of training  and treatment availability.
SPRAY CHARACTERISATION TESTING FOR ORALLY INHALED AND NASAL DRUG PRODUCTS
RESPIRATORY
Francois Billard
Recipharm
SPRAY CHARACTERISATION TESTING FOR ORALLY INHALED AND NASAL DRUG PRODUCTS
Francois Billard and Lei Mao look at measurement systems for spray pattern and plume geometry dispensed by orally inhaled and nasal drug products.
BIOCOMPATIBILITY OF MEDICINAL PRODUCT MEDICAL DEVICE COMBINATIONS FOR AIRWAY DELIVERY
EXPERT VIEW
Mark Turner
BIOCOMPATIBILITY OF MEDICINAL PRODUCT MEDICAL DEVICE COMBINATIONS FOR AIRWAY DELIVERY
Mark Turner discusses biocompatibility testing for inhaled medical products, with particular reference to ISO 18562, and what Medical Engineering Technologies has learned from three years of breathing component biocompatibility testing.
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