ONdrugDelivery | Global Drug Delivery Industry Information & Intelligence

DUAL CHAMBER

Interview: Making Dual-Chamber Systems a Viable Alternative

In this exclusive interview, Laxman Halleppanavar and Guy Furness discuss industry trends and challenges with injectable delivery, and how Credence MedSystems' dual-chamber devices provide solutions to address those challenges, including overcoming the barriers posed by supply chain management.

TWO INTO ONE: SOLVING COMPLEX DRUG DELIVERY PROBLEMS WITH DUAL-CHAMBER CONTAINMENT SOLUTIONS

Enrico Barichello and Valerio Ravazzolo describe how dual-chamber solutions ensure isolation, integrity and safety for managing lyophilised and liquid drugs. With innovative and customisable designs, these technologies improve drug delivery, reduce contamination risks and simplify complex therapies, addressing the evolving needs of both pharmaceutical industry and patients.

BEYOND THE BARREL: A DUAL-CARTRIDGE IMPROVEMENT TO TRADITIONAL DUAL-CHAMBER DEVICES

Dr Brent Buchine explores how Windgap Medical’s devices transform dual-chamber systems with a modular, scalable and remarkably simple approach to reconstitution and complex drug delivery.

HIGH SPEED LASER ASSEMBLY – FLEXIBLE MACHINE CONCEPTS WITH FULL LASER INTEGRATION

INDUSTRIALISATION

Matthias Müller

HIGH SPEED LASER ASSEMBLY – FLEXIBLE MACHINE CONCEPTS WITH FULL LASER INTEGRATION

Matthias Müller discusses the advantages of including laser technology in drug delivery device manufacturing, covering the various ways in which this technology can be applied and used to provide efficient, cost-effective and clean processes at high throughput rates.

DE-RISKING A NOVEL VALVE COMPONENT FOR USE WITH STANDARD SYRINGE AND AUTOINJECTOR PLATFORMS

BD (Becton Dickinson & Company)

DE-RISKING A NOVEL VALVE COMPONENT FOR USE WITH STANDARD SYRINGE AND AUTOINJECTOR PLATFORMS

Marc Flippe and Sophie Lelias introduce a novel valve component designed to enable dual-chamber functionality within standard syringe and autoinjector platforms. Developed through a comprehensive modelling and development framework, the BD dual-injection syringe system provides a scalable solution to dual-chamber injection that reduces the burden of change by preserving compatibility with established container formats and device architectures.

IMPROVING THE SELF-ADMINISTRATION OF LYO- AND LIQUID-LIQUID FORMULATIONS

Bjørn Knud Andersen

Phillips Medisize

IMPROVING THE SELF-ADMINISTRATION OF LYO- AND LIQUID-LIQUID FORMULATIONS

Bjørn Andersen and Iain Simpson explore the factors contributing to interest in lyo-liquid and liquid-liquid drug delivery, highlighting some of the current unmet needs in this space. Following this, they discuss how platform technologies, such as electromechanical drives, may help address these unmet needs.

ADVANCING LYOPHILISED DRUG DELIVERY WITH REUNITE™: RECONSTITUTION MADE SIMPLE

ADVANCING LYOPHILISED DRUG DELIVERY WITH REUNITE™: RECONSTITUTION MADE SIMPLE

Dr Nina Fetz introduces SHL Medical's Reunite^®, the first and only commercialised dual-chamber cartridge, three-step autoinjector featuring the company’s Needle Isolation Technology. With automated reconstitution, Reunite enables reliable self-injection of lyophilised formulations, supporting home-based care models.

FROM HOSPITAL TO HOME HEALTHCARE: ADVANCES IN LYOPHILISED PRODUCT DELIVERY

Edward Trappler

FROM HOSPITAL TO HOME HEALTHCARE: ADVANCES IN LYOPHILISED PRODUCT DELIVERY

Edward Trappler, Denise Miller and Michael Thomas discuss the challenges for lyophilised products and consider the role of dual-chamber devices in simplifying reconstitution, particularly for at-home healthcare products, and go on to look at how future advances in delivery devices are providing safe solutions for self-administration while improving patient adherence.

POWDER TO THE PEOPLE: ACCELERATING ACCESS TO LYOPHILISED THERAPIES

Kristien De Clercq

POWDER TO THE PEOPLE: ACCELERATING ACCESS TO LYOPHILISED THERAPIES

Kristien De Clercq and Dr Alex Vasiev discuss the challenges and recent advances in drying and reconstitution technologies, as well as how, while dual-chamber primary packaging offers a potential solution for simplifying reconstitution, it remains underused due to usability concerns and a prevailing industry preference for vial-based lyophilisation over alternative drying methods such as spray drying and powder filling.

ADVANCING LYOPHILISED DRUG DEVELOPMENT IN DUAL-CHAMBER SYSTEMS

Dr Markus Neumeier

ADVANCING LYOPHILISED DRUG DEVELOPMENT IN DUAL-CHAMBER SYSTEMS

Dr Markus Neumeier details the lyophilisation process and the range of elements that need to be examined for a dual-chamber system undergoing freeze-drying, while also laying out the quality control processes to conduct when transitioning from the laboratory to industrial-scale operations.

Early Insight: RETHINKING DUAL-CHAMBER SYRINGES: A LATERAL APPROACH TO FASTER, SAFER RECONSTITUTION

Early Insight: RETHINKING DUAL-CHAMBER SYRINGES: A LATERAL APPROACH TO FASTER, SAFER RECONSTITUTION

Eric Sugalski examines the limitations of current concentric dual-chamber syringe designs and explores a novel, lateral-chamber approach from Ampulis – the Ampulis Reconstitution Syringe.

Early Insight: DuoVIAL<sup>®</sup> – PROTECT, MIX AND DELIVER

Early Insight: DuoVIAL^® – PROTECT, MIX AND DELIVER

Gareth Pearce introduces Pacifi's DuoVIAL^® primary packaging technology for topical lyophilised formulations – a minimalist dual-chamber drug delivery system that enables safer, easier and more cost-effective reconstitution, while retaining the proven materials, formats and filling processes well established in the pharmaceutical sector.

DELIVERING COMPLEXITY: DEVICE CONSIDERATIONS FOR TWO-COMPONENT INJECTABLE FORMULATIONS

María FM Balson

DELIVERING COMPLEXITY: DEVICE CONSIDERATIONS FOR TWO-COMPONENT INJECTABLE FORMULATIONS

María FM Balson weighs up strengths and limitations when developing devices for lyophilised injectables, exploring their growing demand and the impacts of formulation, device type and design on the feasibility for bringing a device to market to deliver these essential therapies.

PDA Universe of Pre-Filled Syringes & Injection Devices Conference

21st Oct 2025 - 22nd Oct 2025

Vienna, Austria

PDA Universe of Pre-Filled Syringes & Injection Devices Conference

This year’s theme for PDA Universe of Pre-Filled Syringes and Injection Devices Conference is Shaping the Drug Delivery Ecosystem, which explores the intersection of science, technology, patient experience, and sustainability in injectable combination products. Key Topics include: User Engagement & Digital Health; Advanced Delivery Systems: Large-volume injections, wearable devices, and new platform technologies; Smart Testing & Automation; and Sustainable Innovation.

DIVERGENT DESIGN PHILOSOPHIES IN THE WEARABLE INJECTOR SEGMENT

DIVERGENT DESIGN PHILOSOPHIES IN THE WEARABLE INJECTOR SEGMENT

Reto Jost and Daniel Käser detail how Ypsomed is approaching wearable injector design with YpsoDose and achieving large-volume requirements, consistent dosing and low residual waste, going on to explain how the company’s design choices are integrated with patient-centric features to ensure adherence and comfort.

SYMBIOZE<sup>®</sup> – THE ELECTROMECHANICAL ON-BODY DRUG DELIVERY SYSTEM FOR LARGE-VOLUME IMMUNOTHERAPIES

SYMBIOZE^® – THE ELECTROMECHANICAL ON-BODY DRUG DELIVERY SYSTEM FOR LARGE-VOLUME IMMUNOTHERAPIES

Corinne Malica and Cécile Gross discuss the challenges involved in developing a wearable device for on-body drug delivery of advanced biologics, with a focus on the immunotherapy sector, and the technical solutions that can overcome them, using Nemera’s Symbioze^® as an example.

ADVANCING CANCER CARE THROUGH ON-BODY SUBCUTANEOUS INJECTIONS: THE ONCOLOGY COMMUNITY’S PERSPECTIVE

ADVANCING CANCER CARE THROUGH ON-BODY SUBCUTANEOUS INJECTIONS: THE ONCOLOGY COMMUNITY’S PERSPECTIVE

Dr Greg Moakes discusses the role that on-body delivery systems have to play in modernising the delivery of oncology drugs, digging into the survey results of over 200 attendees of the American Society of Clinical Oncology 2025 Global Meeting as to their opinions on the place of this pivotal technology in oncological practice.

DEVICE DESIGN TO ADDRESS USABILITY AND MITIGATE USE-RELATED RISKS – A MEDICAL AFFAIRS AND HUMAN FACTORS PERSPECTIVE

Dr Sylvine Raverdy-Wilson

BD (Becton Dickinson & Company)

DEVICE DESIGN TO ADDRESS USABILITY AND MITIGATE USE-RELATED RISKS – A MEDICAL AFFAIRS AND HUMAN FACTORS PERSPECTIVE

Dr Sylvine Raverdy-Wilson deep dives into the device constituent of drug-device combination product design and shares perspectives through the Use-Related Risk Analysis methodology with a focus on the BD Libertas™ Wearable Injector.

VISTA BY TXSPHERE: TRAVERSING THE LIMITATIONS OF SMALL-VOLUME BIOLOGICS

Dr Chaoyoung Lee

VISTA BY TXSPHERE: TRAVERSING THE LIMITATIONS OF SMALL-VOLUME BIOLOGICS

Dr Chaoyoung Lee and Mike Stout unveil an innovative addition to TxSphere's wearable platform, Vista, designed to improve on efficiency goals, adapt to varied drug formulations and advance beyond the requirements of low-volume drug delivery.

INJECTING DRUGS DIRECTLY INTO THE BODY: HOW ON-BODY DELIVERY SYSTEMS ARE REVOLUTIONISING THERAPY

INJECTING DRUGS DIRECTLY INTO THE BODY: HOW ON-BODY DELIVERY SYSTEMS ARE REVOLUTIONISING THERAPY

Peter Schmidt discusses the advantages of on-body delivery systems and what makes them special, going on to consider the significant role that they are expected to play in the future of injection technology for the pharmaceutical and medical fields, as well as the role that comprehensive testing plays in bringing this technology to patients.

ACCELERATING DEVELOPMENT OF ELECTROMECHANICAL DELIVERY SYSTEMS VIA MODULAR INTEGRATION

Nicholas Ciccarelli

ACCELERATING DEVELOPMENT OF ELECTROMECHANICAL DELIVERY SYSTEMS VIA MODULAR INTEGRATION

Nicholas Ciccarelli, Andrew King, Dr Marcus Herrmann and Dr Thomas Roschke, discuss the insights gained in the product development process from the recent collaboration between the two companies, with Kymanox managing the overall system integration and Johnson MedTech tackling the specific design of the drive system within the designated product specification.

SAFE AND SKIN-FRIENDLY MANUFACTURING OF MEDICAL WEARABLES WITH ULTRASONIC WELDING

Michael Boerner

SAFE AND SKIN-FRIENDLY MANUFACTURING OF MEDICAL WEARABLES WITH ULTRASONIC WELDING

Michael Boerner looks at the key factors for designing skin-friendly medical wearables and how to manufacture them safely, automatically and sustainably.

SELF-INJECTION DEVICE MANUFACTURING IN A DYNAMIC WORLD

INDUSTRIALISATION

Philipp Richard

SELF-INJECTION DEVICE MANUFACTURING IN A DYNAMIC WORLD

Philipp Richard scrutinises the efficient production of self-injection devices in the pharma industry and describes Ypsomed’s own platforms for developing these devices, highlighting the need to be adaptable and resilient to the rapidly evolving world of drug development. He provides valuable insights into the ways in which the flexible manufacture of self-injection devices might be achieved.

Interview: SHL Advantec – SHL Medical’s New Manufacturing Equipment Sub-Group

Gilbert Fluetsch

Interview: SHL Advantec – SHL Medical’s New Manufacturing Equipment Sub-Group

Gilbert Fluetsch discusses the establishment of SHL Advantec and the foundation it has built as SHL Medical’s in-house equipment specialist. Mr Fluetsch also looks at the role of modular platforms in scaling production and how the company’s global network is designed to support the changing landscape of medical and pharma manufacturing.

FINDING COMMON GROUND: FACTORS FOR ESTABLISHING AND SAFEGUARDING SHELF LIFE IN COMBINATION PRODUCTS

INDUSTRIALISATION

West Pharmaceutical Services

FINDING COMMON GROUND: FACTORS FOR ESTABLISHING AND SAFEGUARDING SHELF LIFE IN COMBINATION PRODUCTS

Lauren Orme discusses the regulatory considerations that need to be taken into account when designing combination products. She reviews the essential testing and standards required for both drug and device when establishing their shelf life and storage in a combined product.

Interview From Pilot to Scale Manufacturing

Interview From Pilot to Scale Manufacturing

In this second exclusive interview with ONdrugDelivery, Glenn Svedberg talks with Guy Furness about Nolato’s role as a strategic partner for design, development and industrialisation within the pharmaceutical sector. In an engaging conversation, Mr Svedberg covers a wide range of subjects about Notalo, including the company’s virtual factory, decentralised structure, approach to scaling up from single-cavity moulds to commercial production, regulatory expertise and global footprint, discussing how the company can use each of these elements to support its partners’ device development and industrialisation programmes.

SHORTENING AND DECARBONISING THE INHALATION SUPPLY CHAIN

INDUSTRIALISATION

SHORTENING AND DECARBONISING THE INHALATION SUPPLY CHAIN

Louise Righton examines the potential for reducing emissions across the pMDI supply chain, considering the localisation of suppliers to shorten supply chains as well as strong partnerships for developing novel, low-carbon alternatives to current high-emission pMDI manufacturing processes.

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