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OCULAR

OCULAR
GLAUCOMA IN VIEW: IMPROVING PATIENT ADHERENCE WITH MULTIDOSE EYEDROPPERS FOR PRESERVATIVE-FREE SOLUTIONS
Zoë Davidson considers the impact of glaucoma on global health and the challenges presented by the increasing prevalence of this disease in the ageing global population, discussing how Novelia®, Nemera’s multidose eyedropper for preservative-free formulations, is well-positioned to address many of the challenges presented by glaucoma treatments, from ease of use to sustainability.
OCULAR
A NEW DELIVERY PLATFORM FOR SUPRACHOROIDAL ADMINISTRATION USING WEST’S ADVANCEABLE MICRONEEDLE DEVICE
Anu Prabhathachandran, Menachem Peretz and Manali Potnis discuss the growing need for more effective delivery of ophthalmic therapeutics to meet the needs of the ageing population, including how delivery into the suprachoroidal space may present an appealing alternative to intravitreal injection. They introduce West Pharmaceutical Service’ Suprachoroidal Advanceable Microneedle Device, which offers several advantages for overcoming the challenges with suprachoroidal space.
A COMPREHENSIVE APPROACH TO ADDRESSING UNMET NEEDS IN INTRAVITREAL INJECTIONS
OCULAR
Dr Reza Abedian
Gerresheimer
A COMPREHENSIVE APPROACH TO ADDRESSING UNMET NEEDS IN INTRAVITREAL INJECTIONS
Dr Reza Abedian, Marie Stockton and Bernd Zeiss consider the complexities and clinical unmet needs of intravitreal injections and discuss how Gerresheimer’s syringe technology can help overcome these challenges.
GENE THERAPY IN OPHTHALMOLOGY: ADVANCES AND CHALLENGES
EXPERT VIEW
Dr Joe Batley
GENE THERAPY IN OPHTHALMOLOGY: ADVANCES AND CHALLENGES
Joe Batley and Lorna Barron provide an overview of the latest cutting-edge ophthalmic delivery methods and discuss possible future developments.
REVOLUTIONISING EYE CARE: THE POTENTIAL OF ANTISENSE OLIGONUCLEOTIDES
EXPERT VIEW
Binbin Tian
REVOLUTIONISING EYE CARE: THE POTENTIAL OF ANTISENSE OLIGONUCLEOTIDES
Binbin Tian discusses antisense oligonucleotides and considers their potential as treatments for genetic and multifactorial ophthalmic diseases previously considered untreatable. The article considers how these therapies function as treatments, their current state of development, challenges in their delivery and the evolving regulatory landscape
INTRODUCING THE TERUMO INJECTION FILTER NEEDLE – A FIRST STEP OF THE INFINO™ DEVELOPMENT PROGRAMME
INJECTION
Thomas Isaac
Terumo Medical Care Solutions
INTRODUCING THE TERUMO INJECTION FILTER NEEDLE – A FIRST STEP OF THE INFINO™ DEVELOPMENT PROGRAMME
Thomas Isaac considers the issues associated with injection to highly sensitive areas, such as the vitreous body, and the potential to optimise needle design and features to address these issues, discussing the key features of Terumo’s Injection Filter Needle, indicated for hypodermic and intravitreal injections within this context.
510(k) CLEARED, USER-FILLED MICRODOSING DEVICE FOR OPHTHALMIC AND OTHER APPLICATIONS
PREFILLED SYRINGES
Dr Gautam Shetty
Congruence Medical Solutions
510(k) CLEARED, USER-FILLED MICRODOSING DEVICE FOR OPHTHALMIC AND OTHER APPLICATIONS
Gautam Shetty discusses unmet drug delivery needs in applications requiring accurate and precise microlitre-scale doses,going on to detail how the Congruence Medical’s recently cleared Microliter Dosing Syringe can bring the benefits of advanced syringe materials and performance to these applications.
ADDRESSING INTRAVITREAL PRODUCT MANUFACTURING AND DEVELOPMENT CHALLENGES
OCULAR
Dr Andrea Allmendinger
ten23 health
ADDRESSING INTRAVITREAL PRODUCT MANUFACTURING AND DEVELOPMENT CHALLENGES
Andrea Allmendinger, Hanns-Christian Mahler and Philipp Behrendt discuss the challenges of filling very small volumes into syringes for intravitreal injections, and how ten23’s innovative filling technology can help combat the critical issue of air bubble formation.
INTERVIEW: UNITHER PHARMACEUTICALS’ INNOVATIVE APPROACH TO OPHTHALMIC MANUFACTURING
INTERVIEW
Natalia Servol
Unither Pharmaceuticals
INTERVIEW: UNITHER PHARMACEUTICALS’ INNOVATIVE APPROACH TO OPHTHALMIC MANUFACTURING
Natalia Servol shares insights into Unither Pharmaceutical’s preservative-free multidose technology. With a focus on addressing patient needs and meeting industry demands, the company offers a distinctive approach to sterile manufacturing in the ophthalmic sector.
COMPARATIVE USABILITY STUDY OF MULTIDOSE PRESERVATIVE-FREE EYE DROP DEVICES
OCULAR
Rouven Kraus
Aero Pump
COMPARATIVE USABILITY STUDY OF MULTIDOSE PRESERVATIVE-FREE EYE DROP DEVICES
Rouven Kraus discusses the results of a study investigating dose accuracy and reproducibility, along with user preferences, for a variety of multidose preservative-free eye drop devices.
LISTENING TO THE PATIENT’S VOICE TO IMPROVE EYE CARE
OCULAR
Zoe Davidson
Nemera
LISTENING TO THE PATIENT’S VOICE TO IMPROVE EYE CARE
 Zoë Davidson discusses the benefits of collaborating with patients to improve eye care management.
ACCURATE DELIVERY & PRECISE DOSING OF EYE DROPS: WHAT IF WE CHANGE THE INSTILLATION PROCEDURE?
EARLY INSIGHT
Dr Philippe Daull
Akrivision Technologies
ACCURATE DELIVERY & PRECISE DOSING OF EYE DROPS: WHAT IF WE CHANGE THE INSTILLATION PROCEDURE?
Philippe Daull and Pierre Roy discuss how changing the administration procedure for eye drops can improve the patient experience and eliminate health risks.
DRUG DELIVERY TRENDS FOR 2024
EXPERT VIEW
Tom Oakley
Springboard
DRUG DELIVERY TRENDS FOR 2024
Tom Oakley and Kamaal de Silva consider how keeping abreast of the latest trends can help the industry predict and prepare for the future and, commenting from Springboard's privileged position at the centre of many of the drug delivery sector’s most exciting developments, discuss the top trends to look out for in 2024.
GREEN THINKING: HOW TO BECOME A MORE SUSTAINABLE ORGANISATION
SUSTAINABILITY
André Jansen
IGS GeboJagema
GREEN THINKING: HOW TO BECOME A MORE SUSTAINABLE ORGANISATION
André Jansen and Ron Cisliek describe how high-precision mould maker IGS GeboJagema is fostering a culture of “green thinking” and making sustainability a core part of its business.
ACQUIRING A LIQUID BIOPSY INCIDENTAL TO INTRAVITREAL INJECTION
EARLY INSIGHT
Dr Alex Tumlinson
ACQUIRING A LIQUID BIOPSY INCIDENTAL TO INTRAVITREAL INJECTION
Alexandre Tumlinson introduces Twenty/Twenty Therapeutics' VitreoDx injection system to address emerging trends in intravitreal therapeutics.
OPTIMISING MICROLITRE DOSING: CASE STUDY WITH INTRAVITREAL INJECTION
OCULAR
Yuki Takeuchi
Terumo Medical Care Solutions
OPTIMISING MICROLITRE DOSING: CASE STUDY WITH INTRAVITREAL INJECTION
Yuki Takeuchi and Richard Whelton discuss the challenges of delivering intravitreal injections and how the combination of Terumo’s PLAJEX™ prefillable syringes with Congruence’s Microlitre Dosing Syringe system is able to address them.
OVERCOMING CHALLENGES WHEN DEVELOPING OLIGONUCLEOTIDES FOR OPHTHALMIC DRUGS
EXPERT VIEW
Dr Shiyan Chen
OVERCOMING CHALLENGES WHEN DEVELOPING OLIGONUCLEOTIDES FOR OPHTHALMIC DRUGS
Shiyan Chen and Binbin Tian discuss the use of oligonucleotides for ophthalmic applications, including their potential uses, advantages, challenges and difficulties when it comes to pharmacokinetic and drug metabolism studies.
INTRAVITREAL INJECTIONS – MORE THAN MEETS THE EYE: A TECHNICAL VIEW OF PRODUCT USE
OCULAR
Dr Andrea Allmendinger
ten23 health
INTRAVITREAL INJECTIONS – MORE THAN MEETS THE EYE: A TECHNICAL VIEW OF PRODUCT USE
Andrea Allmendinger and Hanns-Christian Mahler highlight the technical challenges of intravitreal administration and considerations from the ophthalmologist’s and patient’s perspectives.
DRUG DELIVERY PLATFORM DRIVES NEW OPPORTUNITIES FOR CONTINUOUS-DELIVERY GLAUCOMA TREATMENT
OCULAR
Dr Harsh Patel
Celanese
DRUG DELIVERY PLATFORM DRIVES NEW OPPORTUNITIES FOR CONTINUOUS-DELIVERY GLAUCOMA TREATMENT
Harsh Patel, Cyonna Holmes and Brian Wilson discuss how Celanese’s VitalDose® EVA drug delivery platform can help reduce intraocular pressure by creating a desired therapeutic release profile.
GROUNDBREAKING TREND FOR PRESERVATIVE-FREE MULTIDOSE EYE DROPS IN THE US
OCULAR
Rouven Kraus
Aero Pump
GROUNDBREAKING TREND FOR PRESERVATIVE-FREE MULTIDOSE EYE DROPS IN THE US
Rouven Kraus discusses the increasing trend towards preservative-free formulations in ophthalmic drug delivery and the challenges presented by regulatory demands on new drug products in the space.
NOVELIA<sup>®</sup>: A CLEAR VISION FOR EYE CARE FOR PATIENTS GLOBALLY
OCULAR
Zoe Davidson
Nemera
NOVELIA®: A CLEAR VISION FOR EYE CARE FOR PATIENTS GLOBALLY
Zoë Davidson discusses the benefits of Novelia®, Nemera’s alternative to sterile filters for multidose eye droppers for preservative-free formulations.
MISTGO<sup>®</sup> – A NEW MICRODOSING EYE MEDICATION DELIVERY SYSTEM
EARLY INSIGHT
Rie Saabye
EYE-GO
MISTGO® – A NEW MICRODOSING EYE MEDICATION DELIVERY SYSTEM
Rie Saabye and Morten Jacobsen discuss the benefits of a new microdosing eye medication delivery system for chronic ophthalmic diseases, such as dry eye disease and glaucoma.
TOPICAL DRUG ADMINISTRATION FOR THE POSTERIOR SEGMENT
EXPERT VIEW
Dr David Bingaman
TOPICAL DRUG ADMINISTRATION FOR THE POSTERIOR SEGMENT
David Bingaman explores the potential benefits of topical administration for diseases affecting the posterior segment of the eye.
BEYOND THE EYEDROPPER BOTTLE – THREE WAYS TO IMPROVE ADHERENCE
EXPERT VIEW
Dr Nathan Wilkinson
BEYOND THE EYEDROPPER BOTTLE – THREE WAYS TO IMPROVE ADHERENCE
Nathan Wilkinson, Catherine Wyman and Matt Parker discuss the future outlook of ophthalmic drug delivery beyond the traditional eyedropper bottle, including new delivery technologies, sustained-release therapeutics and digital healthcare applications.
A SIGHT FOR SORE EYES: CHALLENGES & INNOVATIONS IN OPHTHALMIC DRUG DELIVERY
EXPERT VIEW
Dr Ethan Miller
A SIGHT FOR SORE EYES: CHALLENGES & INNOVATIONS IN OPHTHALMIC DRUG DELIVERY
Ethan Miller and Kristien De Clercq discuss recent advancements and current challenges in the field of ophthalmology, including the trend towards preservative-free multidose delivery systems, delivering smaller topical volumes with increased drug efficacy, slow-release injections for delivery to the posterior of the eye and the exciting field of gene therapy.
SILICONE-OIL-FREE PREFILLED SYRINGE SYSTEMS – GUIDANCE FOR SELECTING THE APPROPRIATE PACKAGING MATERIALS AND FOR SILICONISATION
PREFILLED SYRINGES
Bernd Zeiss
Gerresheimer
SILICONE-OIL-FREE PREFILLED SYRINGE SYSTEMS – GUIDANCE FOR SELECTING THE APPROPRIATE PACKAGING MATERIALS AND FOR SILICONISATION
Bernd Zeiss addresses the influence of silicone oil on syringe systems and highlights the advantages and possibilities of novel silicone-oil-free prefillable syringes, both for glass and for plastic syringes.
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