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Pulmonary & Nasal Drug Delivery145

Issue No #145 April 2023  April 22nd, 2023


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Inside the magazine

ACCELERATING THE GO-TO-MARKET OF NASAL COMBINATION PRODUCTS WITH INTEGRATED SOLUTIONS
NASAL
Séverine Duband
Nemera
ACCELERATING THE GO-TO-MARKET OF NASAL COMBINATION PRODUCTS WITH INTEGRATED SOLUTIONS
Séverine Duband and Audrey Chandra discuss emerging trends in the ear, nose and throat market and how Nemera can assist in bringing new devices to market.
NAVIGATING pMDI REFORMULATION 2.0
SUSTAINABILITY
Chris Baron
Aptar Pharma
NAVIGATING pMDI REFORMULATION 2.0
Chris Baron and William Ganley examine possible responses to the environmental impact of pressurised metered dose inhalers use and consider alternative inhaler types, with a focus on the strategies and support that can accelerate the development of the next generation of pMDIs.
NAVIGATING THE CHALLENGES OF BRINGING INTRANASAL DRUG FORMULATIONS & DEVICES TO PATIENTS
NASAL
Joe Neale
Recipharm
NAVIGATING THE CHALLENGES OF BRINGING INTRANASAL DRUG FORMULATIONS & DEVICES TO PATIENTS
Joe Neale and Ross Errington explore the obstacles and opportunities facing the intranasal drug delivery market and how manufacturers can overcome them by harnessing innovative platforms like Unidose® Xtra.
CONNECT IN PHARMA REPORT: FUTURE TRENDS IN DRUG DELIVERY DEVICES
CONFERENCE SHOWCASE
CONNECT IN PHARMA REPORT: FUTURE TRENDS IN DRUG DELIVERY DEVICES
A new report from the organisers of Connect in Pharma, “The Future of Pharma Production, Manufacturing and Packaging Trend Report”, has highlighted a range of forces shaping the future of the pharmaceutical manufacturing and drug-delivery industry.
THE APPLICATION DIVERSITY OF METERED PUMP-BASED SOFT MIST DEVICES
PULMONARY
Dr Marie-Christine Klein
URSATEC
THE APPLICATION DIVERSITY OF METERED PUMP-BASED SOFT MIST DEVICES
Marie-Christine Klein, Andreas Bilstein and Caroline Hoffmann discuss the underlying techniques involved in the use of metered pump-based soft mist devices and their application diversity.
NOVEL INDUSTRIAL-SCALE ELECTROSTATIC CHARGE ELIMINATION METHOD FOR INHALATION PRODUCTS
PULMONARY
Dr Orest Lastow
Iconovo
NOVEL INDUSTRIAL-SCALE ELECTROSTATIC CHARGE ELIMINATION METHOD FOR INHALATION PRODUCTS
Orest Lastow describes a novel technique for removing the built-up charge from dry powder inhaler components, offering a potential solution to the issues caused by static charges in these devices, including decreased performance, altered powder properties and increased variability in delivered dose.
DEVELOPMENT APPROACH FOR A HIGH-PERFORMANCE CAPSULE-BASED DPI
PULMONARY
Dr Mirjam Kobler
H&T Presspart
DEVELOPMENT APPROACH FOR A HIGH-PERFORMANCE CAPSULE-BASED DPI
Mirjam Kobler, Ameet Sule and Sunita Sule look at the factors affecting the performance of dry powder inhalers and discuss the company’s development of high-performance prototypes.
ARE YOU STRUGGLING TO PUT DIFFICULT POWDERS INTO CAPSULES?
PULMONARY
Andy Cleall
3P Innovation
ARE YOU STRUGGLING TO PUT DIFFICULT POWDERS INTO CAPSULES?
Andy Cleall and Ben Smith discuss process optimisation and cutting-edge technology for powder filling, including how 3P’s R500 and R1000 robotic capsule fillers are pushing the boundaries of optimal filling and how its Fill2Weight technology enables increased filling accuracy and improved yields.
THE POTENTIAL AND THE CHALLENGES OF NASAL VACCINATION
NASAL
Dr Julie Suman
Aptar Pharma
THE POTENTIAL AND THE CHALLENGES OF NASAL VACCINATION
Julie Suman and Nektaria Karavas discuss the challenges and opportunities of intranasal vaccination – showcasing current understanding for both liquid and powder products. Experimental studies highlight critical issues, the performance of commercially available devices and developments in formulation practice.
CAPSULE FILLING FOR DPIs – LINKING PROCESS SCALES THROUGH ADVANCED CHARACTERISATION AND QUALITY BY DESIGN
PULMONARY
Dr Rui Churro
Hovione
CAPSULE FILLING FOR DPIs – LINKING PROCESS SCALES THROUGH ADVANCED CHARACTERISATION AND QUALITY BY DESIGN
 Rui Churro, Carolina Lopes and João Pires discuss the value of rheological characterisation of powders to expedite and de-risk the scale-up of DPI capsule-filling processes.
ISOTHERMAL DRY PARTICLE COATING – BACK TO THE FUTURE?
PULMONARY
Dr Jasdip Koner
Aston Particle Technologies
ISOTHERMAL DRY PARTICLE COATING – BACK TO THE FUTURE?
Jasdip Koner, Abdul Ershad and David Wyatt introduce Aston Particle Technologies’ novel dry powder processing technology – isothermal dry particle coating (iDPC™) – explaining how it has the capacity to enhance and broaden the scope of what dry powder formulations can achieve in respiratory medicine.
DUE DILIGENCE – THE KEY TO SUCCESS IN DRUG DELIVERY DEVICE SELECTION
EXPERT VIEW
Matt Jones
DUE DILIGENCE – THE KEY TO SUCCESS IN DRUG DELIVERY DEVICE SELECTION
Matt Jones and Rob Veasey consider the process of matching the drug with the right delivery device and look at the importance of due diligence when “licensing in” technology.
CONSIDERATIONS WHEN SWITCHING FROM CURRENT pMDI PROPELLANTS TO NEW LOWER-GWP PROPELLANTS
EXPERT VIEW
Mark Parry
CONSIDERATIONS WHEN SWITCHING FROM CURRENT pMDI PROPELLANTS TO NEW LOWER-GWP PROPELLANTS
Mark Parry discusses the considerations that need to be made when switching from current pressurised metered dose inhaler propellants to new alternatives with lower global warming potential, including formulation, regulatory and analytical standpoints.
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